Wang Z, Zhang HM, Guo YR, Li LL. Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study. World J Clin Cases 2022; 10(21): 7224-7241 [PMID: 36158000 DOI: 10.12998/wjcc.v10.i21.7224]
Corresponding Author of This Article
Ling-Ling Li, PhD, Doctor, Department of Dermatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang Road, Dongcheng District, Beijing 100700, China. linglingli1980@163.com
Research Domain of This Article
Dermatology
Article-Type of This Article
Clinical and Translational Research
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Wang Z, Zhang HM, Guo YR, Li LL. Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study. World J Clin Cases 2022; 10(21): 7224-7241 [PMID: 36158000 DOI: 10.12998/wjcc.v10.i21.7224]
World J Clin Cases. Jul 26, 2022; 10(21): 7224-7241 Published online Jul 26, 2022. doi: 10.12998/wjcc.v10.i21.7224
Molecular mechanisms of Biyu decoction as treatment for psoriasis: A network pharmacology and molecular docking study
Zi Wang, Hao-Min Zhang, Yuan-Rui Guo, Ling-Ling Li
Zi Wang, Hao-Min Zhang, Yuan-Rui Guo, Ling-Ling Li, Department of Dermatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Author contributions: Li LL designed the research; Wang Z, Zhang HM, and Guo YR performed the research; Zhang HM, and Guo YR analyzed the data; Wang Z wrote the paper.
Supported bythe National Natural Science Foundation of China (NSFC), No. 81874393.
Institutional review board statement: Because the data from public databases are publicly available and open-access, this study do not require approval by the local ethics committees. This study followed public databases access policies and publication guidelines.
Clinical trial registration statement: This registration policy applies to prospective, randomized, controlled trials only.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that there is no conflict of interest regarding the publication of this paper.
Data sharing statement: Technical appendix, statistical code, and dataset available from the manuscript.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Corresponding author: Ling-Ling Li, PhD, Doctor, Department of Dermatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang Road, Dongcheng District, Beijing 100700, China. linglingli1980@163.com
Received: January 17, 2022 Peer-review started: January 17, 2022 First decision: March 16, 2022 Revised: March 24, 2022 Accepted: June 4, 2022 Article in press: June 4, 2022 Published online: July 26, 2022 Processing time: 174 Days and 19.3 Hours
Core Tip
Core Tip: Biyu decoction has significant effects on psoriasis; however, its molecular targets in psoriasis remain unknown. We conducted a network pharmacology and molecular docking study to determine whether Biyu decoction ingredients target molecules and signaling pathways related to psoriasis pathogenesis. The main active ingredients identified include quercetin, kaempferol, beta-sitosterol, naringenin, and acetyl-shikonin. Target genes included MAPK3, JUN, FOS, MYC, MAPK8, STAT3, and NFKBIA, which can regulate the inflammatory state mediated by psoriasis immune cells and mediate the expression of factors that adjust local skin inflammation. Our results confirm that Biyu decoction can treat psoriasis through multi-component, multi-target, and multi-channel synergy.
