©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2022; 10(19): 6722-6727
Published online Jul 6, 2022. doi: 10.12998/wjcc.v10.i19.6722
Published online Jul 6, 2022. doi: 10.12998/wjcc.v10.i19.6722
Two smoking-related lesions in the same pulmonary lobe of squamous cell carcinoma and pulmonary Langerhans cell histiocytosis: A case report
Aysegul Gencer, Fatma Gulsum Karakas, Sermin Borekci, Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty Campus, Istanbul 34098, Turkey
Gizem Ozcibik, Ismail Sarbay, Akif Turna, Department of Thoracic Surgery, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul 34098, Turkey
Sebnem Batur, Department of Pathology, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul 34098, Turkey
Author contributions: Gencer A and Karakas FG collected the patient data and performed his follow-up; Ozcibik G, Sarbay I and Turna A performed the operation; Batur S performed immunohistochemical analyses; Gencer A, Borekci S and Turna A wrote the paper; all authors have read and approved the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Aysegul Gencer, MD, Academic Research, Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty Campus, Kocamu
Received: February 28, 2022
Peer-review started: February 28, 2022
First decision: April 8, 2022
Revised: April 14, 2022
Accepted: April 24, 2022
Article in press: April 24, 2022
Published online: July 6, 2022
Processing time: 115 Days and 13.1 Hours
Peer-review started: February 28, 2022
First decision: April 8, 2022
Revised: April 14, 2022
Accepted: April 24, 2022
Article in press: April 24, 2022
Published online: July 6, 2022
Processing time: 115 Days and 13.1 Hours
Core Tip
Core Tip: The BRAF mutation is associated with a number of tumors, it is thought that Pulmonary Langerhans cell histiocytosis (PLCH) may be a precursor of malignancy. In this case, the diagnosis of PLCH concurrently with the diagnosis of lung squamous cell carcinoma and the detection of BRAF mutation supported this hypothesis.