©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2022; 10(16): 5446-5455
Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5446
Published online Jun 6, 2022. doi: 10.12998/wjcc.v10.i16.5446
Pediatric acute myeloid leukemia patients with i(17)(q10) mimicking acute promyelocytic leukemia: Two case reports
Hong-Xia Yan, Department of Healthcare, Rainbow Hospital of Xianyang, Xianyang 721000, Shaanxi Province, China
Wei-Hua Zhang, Department of Pediatric Intensive Care Unit, Rainbow Hospital of Xianyang, Xianyang 721000, Shaanxi Province, China
Jin-Quan Wen, Department of Pediatric Hematology/Oncology, Rainbow Hospital of Xianyang, Xianyang 721000, Shaanxi Province, China
Yan-He Liu, Bao-Juan Zhang, A-Duo Ji, Department of Pediatric Hemato
Author contributions: Yan HX and Wen JQ contributed to conception and design of the study; Yan HX and Zhang WH are the co-first author; Zhang WH organized the database; Yan HX wrote the first draft of the manuscript; all authors contributed to manuscript revision, read, and approved the submitted version.
Supported by Shaanxi Natural Science Foundation , No. 2020SF-004 .
Informed consent statement: Consent was obtained from relatives of the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Jin-Quan Wen, BSc, Department of Pediatric Hematology/Oncology, Rainbow Hospital of Xianyang, Rainbow Hospital of Xianyang, Xianyang 721000, Shaanxi Province, China. wenjinquandr@126.com
Received: October 10, 2021
Peer-review started: October 10, 2021
First decision: January 13, 2022
Revised: January 21, 2022
Accepted: April 21, 2022
Article in press: April 21, 2022
Published online: June 6, 2022
Processing time: 235 Days and 7.8 Hours
Peer-review started: October 10, 2021
First decision: January 13, 2022
Revised: January 21, 2022
Accepted: April 21, 2022
Article in press: April 21, 2022
Published online: June 6, 2022
Processing time: 235 Days and 7.8 Hours
Core Tip
Core Tip: Herein we reported two cases of acute myeloid leukemia (AML) mimicking APL after the same treatment protocols. A rare chromosomal abnormality, i(17)(q10), was observed in two pediatric patients, which mimicked acute promyelocytic leukemia (APL) phenotype. Both patients showed no responses to all-trans retinoic acid and arsenic trioxide induction therapy. One patient with i(17)(q10) died after 5 mo, and the other patient with i(17)(q10) add (14)14 had been medication free more than 10 mo and achieved complete tumor remission for 3 years since drugs were withdrawn. Pediatric AML mimicking APL is difficult to treat and additional cases should be studied to provide better treatment strategies for these patients.