Du Y, Wang ZY, Zheng Z, Li YX, Wang XY, Du R. Bronchiolar adenoma with unusual presentation: Two case reports. World J Clin Cases 2022; 10(14): 4541-4549 [PMID: 35663079 DOI: 10.12998/wjcc.v10.i14.4541]
Corresponding Author of This Article
Ran Du, MM, Doctor, Department of Pathology, The Affiliated Hospital of Shandong First Medical University (Liaocheng People’s Hospital), No. 67 Dongchang West Road, Liaocheng 252000, Shandong Province, China. chinaduying@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
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Du Y, Wang ZY, Zheng Z, Li YX, Wang XY, Du R. Bronchiolar adenoma with unusual presentation: Two case reports. World J Clin Cases 2022; 10(14): 4541-4549 [PMID: 35663079 DOI: 10.12998/wjcc.v10.i14.4541]
World J Clin Cases. May 16, 2022; 10(14): 4541-4549 Published online May 16, 2022. doi: 10.12998/wjcc.v10.i14.4541
Bronchiolar adenoma with unusual presentation: Two case reports
Ying Du, Zheng-Yan Wang, Zheng Zheng, Ying-Xue Li, Xiu-Yu Wang, Ran Du
Ying Du, Zheng-Yan Wang, Zheng Zheng, Ying-Xue Li, Xiu-Yu Wang, Ran Du, Department of Pathology, The Affiliated Hospital of Shandong First Medical University (Liaocheng People’s Hospital), Liaocheng 252000, Shandong Province, China
Author contributions: Du Y contributed to the conception and design, data analysis and interpretation, and manuscript writing; Du R contributed to the administrative support; Wang ZY and Wang XY contributed to the provision of study materials or patients; Du Y, Zheng Z, and Li YX contributed to the collection and assembly of data; and all authors have read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from both patients for the publication of this case report.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Ran Du, MM, Doctor, Department of Pathology, The Affiliated Hospital of Shandong First Medical University (Liaocheng People’s Hospital), No. 67 Dongchang West Road, Liaocheng 252000, Shandong Province, China. chinaduying@163.com
Received: August 30, 2021 Peer-review started: August 30, 2021 First decision: November 17, 2021 Revised: December 3, 2021 Accepted: March 25, 2022 Article in press: March 25, 2022 Published online: May 16, 2022 Processing time: 256 Days and 2.5 Hours
Core Tip
Core Tip: In terms of morphology, case 1 had no atypical cells, visible cilia, and bilayer structures in focal areas. Immunohistochemical staining for P63 and cytokeratin (CK)5/6 revealed the lack of a continuous bilayer structure in most areas, and no mutations were found in the genes detected. In case 2, most cells were medium-sized. Furthermore, local cells had atypia, and cilia were found locally. Immunohistochemical staining for P63 and CK5/6 revealed that only heteromorphic cell regions showed a bilayer structure. Human epidermal growth factor receptor-2 gene mutation was identified. Further research is needed to investigate whether these lesions can be called atypical bronchiolar adenoma and whether they are invasive precursor lesions.
