Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 26, 2022; 10(12): 3822-3827
Published online Apr 26, 2022. doi: 10.12998/wjcc.v10.i12.3822
Isolated coagulopathy without classic CRAB symptoms as the initial manifestation of multiple myeloma: A case report
Ya Zhang, Fang Xu, Jing-Jing Wen, Lin Shi, Qiao-Lin Zhou
Ya Zhang, Fang Xu, Jing-Jing Wen, Lin Shi, Qiao-Lin Zhou, Department of Hematology, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China
Author contributions: Zhang Y and Fang Xu F contributed equally to this work; Zhang Y and Xu F designed the study; Zhang Y and Wen JJ collected the data; Zhang Y and Xu F analyzed the data; Zhang Y, Xu F, and Wen JJ interpreted the data; Zhang Y, Xu F, Wen JJ and Shi L prepared the manuscript; Shi L and Zhou QL searched and reviewed the literature.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fang Xu, MD, Academic Fellow, Chief Doctor, Department of Hematology, Mianyang Central Hospital, No. 12 Changjia Alley, Jingzhong Street, Fucheng District, Mianyang 621000, Sichuan Province, China. 147377807@qq.com
Received: July 13, 2021
Peer-review started: July 13, 2021
First decision: November 22, 2021
Revised: December 1, 2021
Accepted: March 4, 2022
Article in press: March 4, 2022
Published online: April 26, 2022
Processing time: 281 Days and 23.8 Hours
Core Tip

Core Tip: Coagulopathy resulting from isolated acquired factorΧ deficiency is uncommon in myeloma. Typical symptoms in multiple myeloma include hypercalcemia, renal disease, anemia and bone diseases (CRAB). Factor Χ deficiency could herald the CRAB symptoms, and was reported to be closely related to amyloidosis. Secondary amyloidosis could be reasonably suspected if factor Χ deficiency is verified in myeloma patient.