Wang JY, Zhang L, Liu J, Yang W, Ma LN. Metabolic syndrome, ApoE genotype, and cognitive dysfunction in an elderly population: A single-center, case-control study. World J Clin Cases 2021; 9(5): 1005-1015 [PMID: 33644164 DOI: 10.12998/wjcc.v9.i5.1005]
Corresponding Author of This Article
Wei Yang, MD, Chief Doctor, Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Medicine, No. 45 Changchun Street, Xicheng District, Beijing 100053, China. yangw_79@163.com
Research Domain of This Article
Geriatrics & Gerontology
Article-Type of This Article
Case Control Study
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Wang JY, Zhang L, Liu J, Yang W, Ma LN. Metabolic syndrome, ApoE genotype, and cognitive dysfunction in an elderly population: A single-center, case-control study. World J Clin Cases 2021; 9(5): 1005-1015 [PMID: 33644164 DOI: 10.12998/wjcc.v9.i5.1005]
World J Clin Cases. Feb 16, 2021; 9(5): 1005-1015 Published online Feb 16, 2021. doi: 10.12998/wjcc.v9.i5.1005
Metabolic syndrome, ApoE genotype, and cognitive dysfunction in an elderly population: A single-center, case-control study
Jie-Yu Wang, Li Zhang, Jia Liu, Wei Yang, Li-Na Ma
Jie-Yu Wang, Li Zhang, Jia Liu, Wei Yang, Li-Na Ma, Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Medicine, Beijing 100053, China
Author contributions: Wang JY, Zhang L, Liu J, and Yang W conceived and designed the research; Zhang L and Liu J collected data and conducted research; Wang JY, Yang W, and Ma LN analyzed and interpreted data; Wang JY and Yang W wrote the initial paper; Yang W and Ma LN revised the paper; Wang JY had primary responsibility for final content; All authors read and approved the final manuscript.
Supported byBasic and Clinical Cooperation Project of Capital Medical University, No. 16JL82.
Institutional review board statement: The protocol for the study was approved by the Ethics Committee of Xuanwu Hospital, Capital Medical University, No. [2108]112. All procedures performed in studies involving human participants were in accordance with the ethics standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethics standards.
Informed consent statement: Written informed consent was obtained from all subjects included in the study.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: The datasets generated during the current study are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Corresponding author: Wei Yang, MD, Chief Doctor, Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Medicine, No. 45 Changchun Street, Xicheng District, Beijing 100053, China. yangw_79@163.com
Received: September 7, 2020 Peer-review started: September 7, 2020 First decision: December 3, 2020 Revised: December 12, 2020 Accepted: December 22, 2020 Article in press: December 22, 2020 Published online: February 16, 2021 Processing time: 145 Days and 0.3 Hours
ARTICLE HIGHLIGHTS
Research background
Cognitive impairment is a serious public problem in the elderly population. Metabolic syndrome (MetS) is increasingly prevalent in the global population. It remains unknown whether MetS is associated with cognitive decline in elderly, and whether distribution of the ApoEε4 allele may modify the association.
Research motivation
To provide pilot evidence regarding the roles of MetS and distribution of ApoEε4 allele with the occurrence of cognitive impairment in elderly population, and to improve the understanding of the association between metabolic components, genetic factors, and cognitive decline.
Research objectives
To clarify the association between MetS, distribution of ApoEε4 allele, and cognitive impairment in an elderly Chinese population and the continuous influence of MetS and distribution of ApoEε4 allele on cognitive function within 1 year.
Research methods
An age- and gender-matched case-control study was performed. The distribution of ApoEε4 was assessed with PCR fragment length polymorphism analysis. Cognitive function was evaluated by mini-mental status examination at the 1-year follow-up examination.
Research results
MetS and ApoEε4 carrier status were potential risk factors related to cognitive dysfunction in an elderly population. No significant interaction between MetS and ApoEε4 was observed. The effects of MetS and ApoEε4 on the deterioration of cognitive function over a 1-year follow-up period were continuous.
Research conclusions
MetS and ApoEε4 carrier status were independently associated with cognitive dysfunction at baseline and within 1 year in an elderly population.
Research perspectives
People with MetS and ApoEε4 carrier status may have a higher risk of cognitive decline. These results may be helpful for the identification of elderly people at high risk for cognitive decline, and targeted intervention against these factors may be beneficial for cognitive function in these people.
