Effects of different statins application methods on plaques in patients with coronary atherosclerosis

doi:10.12998/wjcc.v9.i4.812

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World Journal of Clinical Cases

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World J Clin Cases. Feb 6, 2021; 9(4): 812-821
Published online Feb 6, 2021. doi: 10.12998/wjcc.v9.i4.812

Effects of different statins application methods on plaques in patients with coronary atherosclerosis

Xia Wu, Xiao-Bo Liu, Ting Liu, Wen Tian, Yu-Jiao Sun

Xia Wu, Xiao-Bo Liu, Wen Tian, Yu-Jiao Sun, Department of Geriatrics, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China

Ting Liu, Department of Radiology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China

Author contributions: Wu X participated in the design of the study, acquired the data, performed the statistical analysis, and drafted the manuscript; Liu XB acquired and analysed the data; Liu T and Tian W acquired the data; Sun YJ conceived of the study, participated in its design and coordination, helped to draft the manuscript, and provided critical revision for important intellectual content; all authors approved the final version of the article to be published.

Institutional review board statement: The study was approved by the ethics committee of the First Affiliated Hospital of China Medical University.

Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.

STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.

Corresponding author: Yu-Jiao Sun, MD, Chief Doctor, Department of Geriatrics, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping Ward, Shenyang 110001, Liaoning Province, China. sunyujiaomy08@sina.cn

Received: September 28, 2020
Peer-review started: September 28, 2020
First decision: November 3, 2020
Revised: November 23, 2020
Accepted: December 10, 2020
Article in press: December 10, 2020
Published online: February 6, 2021
Processing time: 119 Days and 1.7 Hours

ARTICLE HIGHLIGHTS

Research background

The cardiovascular benefit of statins depends on their compliance, and the cardiovascular events may be related to discontinued application of statins. However, it is unclear whether different administration methods have an effect on coronary artery plaques.

Research motivation

Taking statins can cause plaque regression, but the effects of discontinued and intermittent statins applications on coronary artery plaques are unclear.

Research objectives

To analyse the effects of different statin application methods on plaques in patients with coronary atherosclerosis.

Research methods

Patients were divided into three groups: Discontinued application of statins, intermittent application of statins, and sustained application of statins groups. The effects of the different statins application methods on coronary atherosclerotic plaques were assessed.

Research results

The results found the volume change and rate of change in the most severe plaques significantly decreased and correlated positively with low density lipoprotein cholesterol (LDL-C) only in the sustained statins application group, but there were no changes in the intermittent and discontinued statins application groups.

Research conclusions

Only with continuous statin administration can a reduction in LDL-C levels result in plaque volume shrinkage, but not discontinued or intermittent administration of statins.

Research perspectives

It is important to strengthen the management of patients and the promotion of patients' health education, disease knowledge, and medication knowledge to improve patients' medication compliance and truly improve clinical prognosis.