Mao EW, Cheng XB, Li WC, Kan CX, Huang N, Wang HS, Hou NN, Sun XD. Association between serum Sestrin2 level and diabetic peripheral neuropathy in type 2 diabetic patients. World J Clin Cases 2021; 9(36): 11156-11164 [PMID: 35071546 DOI: 10.12998/wjcc.v9.i36.11156]
Corresponding Author of This Article
Xiao-Dong Sun, MD, PhD, Associate Chief Physician, Department of Endocrinology and Metabolism, Clinical Research Center, The Affiliated Hospital of Weifang Medical University, No. 2428 Yuhe Road, Weifang 261031, Shandong Province, China.xiaodong.sun@wfmc.edu.cn
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Case Control Study
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Mao EW, Cheng XB, Li WC, Kan CX, Huang N, Wang HS, Hou NN, Sun XD. Association between serum Sestrin2 level and diabetic peripheral neuropathy in type 2 diabetic patients. World J Clin Cases 2021; 9(36): 11156-11164 [PMID: 35071546 DOI: 10.12998/wjcc.v9.i36.11156]
World J Clin Cases. Dec 26, 2021; 9(36): 11156-11164 Published online Dec 26, 2021. doi: 10.12998/wjcc.v9.i36.11156
Association between serum Sestrin2 level and diabetic peripheral neuropathy in type 2 diabetic patients
Xiao-Dong Sun, Ning-Ning Hou, Hong-Sheng Wang, Na Huang, Cheng-Xia Kan, Wen-Chao Li, Xue-Bing Cheng, En-Wen Mao
En-Wen Mao, Cheng-Xia Kan, Xiao-Dong Sun, Department of Endocrinology and Metabolism, Clinical Research Center, The Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong Province, China
Xue-Bing Cheng, Wen-Chao Li, Na Huang, Hong-Sheng Wang, Ning-Ning Hou, Department of Endocrinology and Metabolism, The Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong Province, China
Author contributions: Mao EW and Cheng XB performed the majority of experiments and wrote the manuscript, contributing equally to this article; Hou NN and Sun XD designed the study and corrected the manuscript; Li WC, Kan CX, Huang N, and Wang HS were involved in the sample collected and analytical tools.
Supported byNational Natural Science Foundation of China, No. 81870593; Natural Science Foundation of Shandong Province of China, No. ZR2020MH106; Medical Health Science and Technology Project of Shandong Province, No. 202003060396 and No. 202003060400; and Quality Improvement of Postgraduate Education in Shandong Province, No. SDYAL19156.
Institutional review board statement: The study was approved by the Medical Ethics Committee of Affiliated Hospital of Weifang Medical University.
Informed consent statement: Informed consent was obtained prior to enrollment.
Conflict-of-interest statement: The authors have nothing to disclose.
Data sharing statement: The original contributions presented in the study are included in the article/supplementary material. Further inquiries can be directed to the corresponding authors.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Corresponding author: Xiao-Dong Sun, MD, PhD, Associate Chief Physician, Department of Endocrinology and Metabolism, Clinical Research Center, The Affiliated Hospital of Weifang Medical University, No. 2428 Yuhe Road, Weifang 261031, Shandong Province, China.xiaodong.sun@wfmc.edu.cn
Received: July 12, 2021 Peer-review started: July 12, 2021 First decision: September 5, 2021 Revised: September 6, 2021 Accepted: November 14, 2021 Article in press: November 14, 2021 Published online: December 26, 2021 Processing time: 164 Days and 13.1 Hours
ARTICLE HIGHLIGHTS
Research background
Diabetic peripheral neuropathy (DPN) is a chronic and serious microvascular complication of diabetes linked to redox imbalance. Sestrin2, a novel inducible stress protein, participates in glucose metabolic regulation and redox homeostasis. However, the association between serum Sestrin2 and DPN remains unclear.
Research motivation
Are there any correlations between serum Sestrin2 levels and DPN? Answering this question will provide significant insight into understanding the roles of Sestrin2 in DPN.
Research objectives
In this study, we explored the association between serum Sestrin2 and DPN in patients with type 2 diabetes mellitus (T2DM).
Research methods
Of 96 T2DM patients and 39 healthy individuals were enrolled in this case-control study. Clinical features and metabolic indices were identified. Serum Sestrin2 was measured. The association between Sestrin2 and DPN was studied.
Research results
Serum Sestrin2 was significantly lower in healthy volunteers than in all T2DM patients combined. T2DM patients without DPN also had significantly higher levels of Sestrin2 than healthy volunteers. However, T2DM patients with DPN had lower circulating Sestrin2 levels compared to T2DM patients without DPN. Bivariate correlation analysis revealed that serum Sestrin2 was positively correlated with body mass index, HbA1c, serum creatinine, triglycerides, fasting glucose, and negatively associated with estimated glomerular filtration rate. After adjustment for gender, age, HbA1c, and diabetes duration, multiple regression analysis revealed that Sestrin2 was independently correlated with body mass index and triglyceride levels. Logistic regression analyses indicated that Sestrin2, diabetes duration, and high-density lipoprotein were strongly associated with DPN.
Research conclusions
We have identified that lower serum Sestrin2 levels are independently associated with DPN.
Research perspectives
Sestrin2 mediates various effects on the complications of diabetes, including DPN. The value of the study promotes scientists to better understand the mechanisms of DPN for treatment.
