Yu Y, Cui WH, Cheng C, Lu Y, Zhang Q, Han RQ. Association between neutrophil-to-lymphocyte ratio and major postoperative complications after carotid endarterectomy: A retrospective cohort study. World J Clin Cases 2021; 9(35): 10816-10827 [PMID: 35047593 DOI: 10.12998/wjcc.v9.i35.10816]
Corresponding Author of This Article
Ru-Quan Han, MD, PhD, Chief Doctor, Professor, Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No. 119, Southwest 4th Ring Road, Fengtai District, Beijing 100070, China. ruquan.han@ccmu.edu.cn
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Retrospective Cohort Study
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Yu Y, Cui WH, Cheng C, Lu Y, Zhang Q, Han RQ. Association between neutrophil-to-lymphocyte ratio and major postoperative complications after carotid endarterectomy: A retrospective cohort study. World J Clin Cases 2021; 9(35): 10816-10827 [PMID: 35047593 DOI: 10.12998/wjcc.v9.i35.10816]
Yun Yu, Wei-Hua Cui, Chan Cheng, Yu Lu, Qing Zhang, Ru-Quan Han, Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Author contributions: Yu Y, Cui WH and Han RQ were major contributors to the design of the current study; Yu Y, Cui WH and Cheng C performed the analyses and interpretation the data and made substantial contributions to the draft manuscript; Lu Y, Zhang Q and Han RQ made great efforts to revise it; all authors have read and approved the final manuscript.
Supported byClinical Medicine Development of Special Funding, No. ZYLX201708 and No. DFL20180502; Beijing Municipal Administration of Hospitals Incubating Program, No. PX2017037; Beijing Hospitals Authority Youth Programme, No. QML20190508; and Beijing Municipal Science & Technology Commission, No. Z191100006619067.
Institutional review board statement: This study was approved by the Ethics Committee of Beijing Tiantan Hospital (KY2017-024-01) and performed conforming to the 1964 Declaration of Helsinki and its later amendments.
Informed consent statement: Given the retrospective nature of the study, the ethics committee waived the need for written informed consent and no registration was required.
Conflict-of-interest statement: The authors declare no competing interests.
Data sharing statement: The original data is available on request from the corresponding author at ruquan.han@ccmu.edu.cn.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Corresponding author: Ru-Quan Han, MD, PhD, Chief Doctor, Professor, Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No. 119, Southwest 4th Ring Road, Fengtai District, Beijing 100070, China. ruquan.han@ccmu.edu.cn
Received: January 28, 2021 Peer-review started: January 28, 2021 First decision: June 15, 2021 Revised: June 27, 2021 Accepted: September 14, 2021 Article in press: September 14, 2021 Published online: December 16, 2021 Processing time: 315 Days and 16.5 Hours
ARTICLE HIGHLIGHTS
Research background
Carotid artery cross-clamping during carotid endarterectomy (CEA) may induce cerebral ischemia–reperfusion injury to activate local inflammatory responses.
Research motivation
There is no consensus on the correlation between neutrophil-to-lymphocyte ratio (NLR) and complications after CEA.
Research objectives
This study aimed to evaluate the association between NLR and major complications after surgery in patients undergoing CEA.
Research methods
The demographics, neutrophil and lymphocyte count in whole blood and postoperative outcomes of patients undergoing CEA were retrospectively analyzed.
Research results
NLR within 24 h after CEA was significantly correlated with major postoperative complications. The incidence of major postoperative complications in the high NLR group was 8.47 times of that in the low NLR group.
Research conclusions
NLR is associated with major postoperative complications in patients undergoing CEA.
Research perspectives
Since early detection and early treatment help improve outcomes, inflammatory markers may become potential treatment targets for patients undergoing CEA.
