Published online Nov 26, 2021. doi: 10.12998/wjcc.v9.i33.10222
Peer-review started: July 7, 2021
First decision: August 18, 2021
Revised: August 18, 2021
Accepted: September 10, 2021
Article in press: September 10, 2021
Published online: November 26, 2021
Processing time: 138 Days and 6.3 Hours
The presence of ground glass opacity (GGO) in lung adenocarcinoma usually indicates the indolent nature of lesions, and the proportion of GGO reflects the malignant degree of pulmonary adenocarcinoma to a certain extent
The prognostic role of GGO on computed tomography (CT) in stage I pulmonary adenocarcinoma patients remains unclear now.
To identify the prognostic value of GGO on CT in lung adenocarcinoma patients who were pathologically diagnosed with tumor-node-metastasis stage I.
Several databases were searched for relevant studies. The hazard ratio and corresponding 95% confidence interval were combined to assess the association between the presence of GGO and prognosis, representing as the overall survival and disease-free survival. Subgroup analysis based on the ratio of GGO was also conducted.
GGO predicted favorable overall survival (P < 0.001) and disease-free survival (P = 0.003). Subgroup analysis based on the ratio of GGO further demonstrated that the proportion of GGO was a good prognostic indicator in pathological stage I pulmonary adenocarcinoma patients, and patients with a higher ratio of GGO showed better prognosis than patients with a lower GGO ratio did.
The presence of GGO on CT predicted favorable prognosis in tumor-node-metastasis stage I lung adenocarcinoma.
Patients with a higher GGO ratio were more likely to have a better prognosis than patients with a lower GGO ratio.