Published online Nov 6, 2021. doi: 10.12998/wjcc.v9.i31.9406
Peer-review started: May 18, 2021
First decision: June 12, 2021
Revised: June 13, 2021
Accepted: September 23, 2021
Article in press: September 23, 2021
Published online: November 6, 2021
Processing time: 164 Days and 9.1 Hours
The artificial liver support system (ALSS) is an effective treatment method for liver failure, but it requires deep venous intubation and long-term indwelling catheterization. However, the coagulation mechanism disorder of basic liver failure diseases, and deep venous thrombosis (DVT) often occur.
The commonly used DVT risk assessment systems are not suitable for the treatment of liver failure using ALSS. The development of new risk assessment indices for DVT is beneficial for patients with liver failure treated using ALSS therapy.
To evaluate the risk factors for DVT following the use of an ALSS and establish a risk assessment score.
This study was divided into three stages. In the first stage, the risk factors for DVT were screened and the patient data were collected, including ALSS treatment information; biochemical indices; coagulation and hematology indices; complications; procoagulant use therapy status; and a total of 24 other indicators. In the second stage, a risk assessment score for DVT after ALSS treatment was developed. In the third stage, the DVT risk assessment score was validated.
A total of 232 patients with liver failure treated with ALSS were enrolled in the first stage, including 12 with lower limb DVT. We then established a scoring system for risk factors. In the validation group, a total of 213 patients with liver failure were treated with ALSS, including 14 with lower limb DVT. When the cutoff value of risk assessment was 3, the specificity and sensitivity of the risk assessment score were 88.9% and 85.7%, respectively.
A simple risk assessment scoring system was established for DVT patients with liver failure treated with ALSS and was verified to have good sensitivity and specificity.
In this study, through the risk assessment of DVT in patients with liver failure, the advantages of other DVT risk assessment systems were fully used and combined with the special clotting state of liver failure to establish a simple scoring system that has good sensitivity and specificity.