Impact of different stereoisomers of inositol on insulin sensitivity of gestational diabetes mellitus patients

doi:10.12998/wjcc.v9.i3.565

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World Journal of Clinical Cases

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World J Clin Cases. Jan 26, 2021; 9(3): 565-572
Published online Jan 26, 2021. doi: 10.12998/wjcc.v9.i3.565

Impact of different stereoisomers of inositol on insulin sensitivity of gestational diabetes mellitus patients

Jing He, Yan-Li Zhang, Li-Ping Wang, Xiao-Chun Liu

Jing He, Yan-Li Zhang, Li-Ping Wang, Xiao-Chun Liu, Department of Obstetrics and Gynecology, Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan 030032, Shanxi Province, China

Author contributions: He J and Zhang YL designed this study and wrote the article; Wang LP drafted the work and collected the data; Liu XC revised the paper for important intellectual content.

Institutional review board statement: The study was reviewed and approved by the Bethune Hospital of Shanxi Province Institutional Review Board [Approval No. YXLL-2020-062].

Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.

Data sharing statement: No additional data are available.

Corresponding author: Xiao-Chun Liu, MD, Associate Professor, Department of Obstetrics and Gynecology, Shanxi Bethune Hospital, Shanxi Medical University, No. 99 Longcheng Street, Taiyuan 030032, Shanxi Province, China. tyxchliu@163.com

Received: October 27, 2020
Peer-review started: October 27, 2020
First decision: November 20, 2020
Revised: November 29, 2020
Accepted: December 6, 2020
Article in press: December 6, 2020
Published online: January 26, 2021
Processing time: 85 Days and 3.2 Hours

ARTICLE HIGHLIGHTS

Research background

Inositol has nine different isomers, of which the most representative of the human body are myoinositol (MI) and D-chiro-inositol (DCI).

Research motivation

The supplementation of inositol significantly improved insulin resistance in gestational diabetes mellitus (GDM) patients, and the effects of DCI on insulin resistance in GDM have not been reported.

Research objectives

Discuss the impact of different stereoisomers of inositol on insulin sensitivity of GDM patients.

Research methods

Eighty GDM pregnant women were divided into four groups according to their specified treatment regimen.

Research results

There was no statistical difference in the baseline data of each group. The levels of 2 h blood glucose, glycosylated hemoglobin, fasting insulin, total cholesterol, and triglyceride in the B, C, and D groups were significantly lower than those in the control group (A group) after treatment (P < 0.05).

Research conclusions

Treatment of different inositol stereoisomers (inositol MI and inositol DCI) can improve insulin sensitivity and reduce insulin resistance in diabetic patients. The inositol DCI was more effective in treating GDM than inositol MI.

Research perspectives

The treatment of diabetes is diversified.