Zheng L, Wen XL, Dai YC. Mechanism of Jianpi Qingchang Huashi Recipe in treating ulcerative colitis: A study based on network pharmacology and molecular docking. World J Clin Cases 2021; 9(26): 7653-7670 [PMID: 34621817 DOI: 10.12998/wjcc.v9.i26.7653]
Corresponding Author of This Article
Yan-Cheng Dai, MD, Director, Professor, Department of Gastroenterology, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, No. 230 Baoding Road, Shanghai 200082, China. daiyancheng2005@sohu.com
Research Domain of This Article
Integrative & Complementary Medicine
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 16, 2021; 9(26): 7653-7670 Published online Sep 16, 2021. doi: 10.12998/wjcc.v9.i26.7653
Mechanism of Jianpi Qingchang Huashi Recipe in treating ulcerative colitis: A study based on network pharmacology and molecular docking
Lie Zheng, Xin-Li Wen, Yan-Cheng Dai
Lie Zheng, Xin-Li Wen, Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi’an 730000, Shaanxi Province, China
Yan-Cheng Dai, Department of Gastroenterology, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200082, China
Author contributions: Zheng L and Dai YC performed the writing and revising of the manuscript; Zheng L and Wen XL contributed to the design of the work and performed overall supervision; Zheng L wrote and revised the paper.
Supported byShaanxi Province Natural Science Basic Research Program-General Project, No. 2019JM-580 and No. 2021SF-314; Project of Shaanxi Administration of Traditional Chinese Medicine, No. 2019-ZZ-JC010; and Key Clinical Specialty Construction Project supported by Hongkou District Health Committee, No. HKZK2020A01.
Institutional review board statement: Since this article is a molecular mechanism study of network pharmacology and does not involve animal experiments and clinical experiments, it does not require the approval of the ethics committee.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Cheng Dai, MD, Director, Professor, Department of Gastroenterology, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai University of Traditional Chinese Medicine, No. 230 Baoding Road, Shanghai 200082, China. daiyancheng2005@sohu.com
Received: December 24, 2020 Peer-review started: December 24, 2020 First decision: May 8, 2021 Revised: May 28, 2021 Accepted: July 7, 2021 Article in press: July 7, 2021 Published online: September 16, 2021 Processing time: 260 Days and 0.9 Hours
ARTICLE HIGHLIGHTS
Research background
Traditional Chinese medicine has played an important role in the treatment of ulcerative colitis (UC), but the specific mechanism of action has not been clarified, which needs further research.
Research motivation
To provide objective basis for the treatment of UC with traditional Chinese medicine.
Research objectives
To investigate the potential mechanism of Jianpi Qingchang Huashi Recipe (JPQCHSR) for the treatment of UC based on network pharmacology and molecular docking.
Research methods
Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was used to extract the active components and action targets of JPQCHSR.
Research results
Through database analysis, a total of 181 active components, 302 targets and 205 therapeutic targets were obtained for JPQCHSR. The key compounds include quercetin, luteolin, kaempferol, etc. The core targets involved STAT3, AKT1, TP53, MAPK1, MAPK3, JUN, TNF, etc. Total 2861 items were obtained by GO enrichment analysis, and 171 items were obtained by KEGG pathway enrichment analysis. The results of molecular docking showed that the key active components in JPQCHSR had certain affinity with the core target.
Research conclusions
The treatment of UC with JPQCHSR is a complex process of multi-component, multi-target and multi-pathway regulation.
Research perspectives
Traditional Chinese medicine has a huge potential mechanism in the treatment of UC.
