Tetramethylpyrazine inhibits proliferation of colon cancer cells in vitro

doi:10.12998/wjcc.v9.i18.4542

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World Journal of Clinical Cases

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World J Clin Cases. Jun 26, 2021; 9(18): 4542-4552
Published online Jun 26, 2021. doi: 10.12998/wjcc.v9.i18.4542

Tetramethylpyrazine inhibits proliferation of colon cancer cells in vitro

Hua Li, Yan-Xu Hou, Yu Yang, Qing-Qiang He, Tian-Hua Gao, Xiao-Feng Zhao, Zhi-Bin Huo, Shu-Bo Chen, Deng-Xiang Liu

Hua Li, Yan-Xu Hou, Qing-Qiang He, Tian-Hua Gao, Xiao-Feng Zhao, Zhi-Bin Huo, Shu-Bo Chen, Deng-Xiang Liu, Institute of Cancer Control, Xingtai People’s Hospital, Xingtai 054001, Hebei Province, China

Yu Yang, School of First Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China

Author contributions: Li H, Hou YX and Yang Y contributed equally to this work; Chen SB and Liu DX designed the research; Li H and Yang Y analyzed the data and drafted the manuscript; Hou YX revised the manuscript critically for important intellectual content and contributed to data analysis; He QQ, Gao TH, Zhao XF, and Huo ZB helped draft the manuscript; all authors read and approved the final manuscript.

Institutional review board statement: Our study was not involving human and animal subjects.

Conflict-of-interest statement: The authors declare no conflict of interest related to this manuscript.

Data sharing statement: No additional data are available.

Corresponding author: Deng-Xiang Liu, PhD, Academic Research, Chief Doctor, Institute of Cancer Control, Xingtai People’s Hospital, No. 16 Hongxing Street, Xingtai 054001, Hebei Province, China. dengxianglfangliao@163.com

Received: January 14, 2021
Peer-review started: January 14, 2021
First decision: March 15, 2021
Revised: March 27, 2021
Accepted: April 22, 2021
Article in press: April 22, 2021
Published online: June 26, 2021
Processing time: 148 Days and 1.3 Hours

ARTICLE HIGHLIGHTS

Research background

Colon cancer is one of the most common malignancies worldwide, and chemotherapy is a widely used strategy in clinical therapy for colon cancer. However, chemotherapy resistance is a major cause of recurrence and disease progression in colon cancer, and thus novel drugs for treatment are urgently needed. Tetramethylpyrazine (TMP), a component of the traditional Chinese medicine Chuanxiong Hort, has been proven to exhibit a beneficial effect in a number of types of malignant tumors.

Research motivation

To investigate the potential anticancer activity of TMP in colon cancer and its underlying mechanisms.

Research objectives

To investigate the potential anticancer activity of TMP in colon cancer and its underlying mechanisms.

Research methods

Colon cancer cells were incubated with different concentrations of TMP. Cell viability was evaluated by crystal violet staining assay and Cell Counting Kit-8 assay, and cell apoptosis and cell cycle were assessed by flow cytometry.

Research results

TMP significantly inhibited the proliferation of colon cancer cells in a dose- and time-dependent manner. In addition, flow cytometry revealed that TMP induced cell cycle arrest at the G0/G1 phase.

Research conclusions

Our study demonstrated that TMP inhibits the proliferation of colon cancer cells in a dose- and time-dependent manner by inducing apoptosis and arresting the cell cycle at the G0/G1 phase.

Research perspectives

Further studies of the mechanisms of TMP in human colon cancer are needed.