Published online Apr 16, 2021. doi: 10.12998/wjcc.v9.i11.2503
Peer-review started: December 7, 2020
First decision: January 25, 2021
Revised: January 28, 2021
Accepted: February 11, 2021
Article in press: February 11, 2021
Published online: April 16, 2021
Processing time: 116 Days and 11.3 Hours
Signet ring cell carcinoma (SRCC) is an uncommon subtype of colorectal cancer (CRC) with short survival time. Several factors influence its prognosis. Until now, there has been no nomogram to predict the outcome of CRC patients with SRCC.
To explore the prognostic factors and build effective nomograms for predicting overall survival (OS) and cause-specific survival (CSS) of CRC patients with SRCC.
To build effective nomograms based on significant prognostic factors for predicting OS and CSS of CRC patients with SRCC.
Data was extracted from the Surveillance, Epidemiology, and End Results database between 2004 and 2015. Multivariate Cox regression analyses were used to identify independent factors. Nomograms were built and validated to predict OS and CSS. Patients were divided into high-risk, moderate-risk, and low-risk groups using the novel nomograms.
In total, 1230 patients were included. Nomograms for OS and CSS were built with the concordance index of 0.737 and 0.758, respectively. The calibration curves and receiver operating characteristic curves demonstrated good predictive accuracy. The novel nomograms stratified patients into high-risk, moderate-risk, and low-risk groups with 5-year probability survival of 6.8%, 37.7%, and 67.0% for OS (P < 0.001), as well as 9.6%, 38.5%, and 67.6% for CSS (P < 0.001), respectively.
Convenient and visual nomograms were constructed and validated to predict the OS and CSS rates for CRC patients with SRCC for the first time, which are superior to the conventional tumor-node-metastasis staging system.
These novel nomograms could be used for accurately predicting survival rates of CRC patients with SRCC, as well as stratifying patients into different risk groups.