Zhang W, Ban Y, Wu YH, Liu JY, Li XH, Wu H, Li H, Chen R, Yu XX, Zheng R. Epidemiological and clinical characteristics of 65 hospitalized patients with COVID-19 in Liaoning, China. World J Clin Cases 2021; 9(10): 2205-2217 [PMID: 33869596 DOI: 10.12998/wjcc.v9.i10.2205]
Corresponding Author of This Article
Rui Zheng, MD, PhD, Chief Physician, Deputy Director, Doctor, Professor, Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. zhengr@sj-hospital.org
Research Domain of This Article
Respiratory System
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
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Zhang W, Ban Y, Wu YH, Liu JY, Li XH, Wu H, Li H, Chen R, Yu XX, Zheng R. Epidemiological and clinical characteristics of 65 hospitalized patients with COVID-19 in Liaoning, China. World J Clin Cases 2021; 9(10): 2205-2217 [PMID: 33869596 DOI: 10.12998/wjcc.v9.i10.2205]
Wei Zhang, Hao Wu, Huan Li, Rui Chen, Xiao-Xu Yu, Rui Zheng, Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Yuan Ban, Yun-Hai Wu, Department of Critical Care Medicine, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China
Jin-Yang Liu, Xing-Hai Li, Department of Infectious Diseases, The Sixth People's Hospital of Shenyang, Shenyang 110006, Liaoning Province, China
Author contributions: Zhang W contributed to study design, data analysis, and manuscript drafting and revision; Ban Y, Wu YH, Liu JY, and Li XH contributed to this work with regard to data collection and manuscript revision; Wu H, Li H, Chen R, and Yu XX contributed to data analysis and manuscript revision; Zheng R had a contribution in conceptual work, study design, and revising of the manuscript; all co-authors have given the final approval of the version to be published.
Supported by345 Talent Program of Shengjing Hospital; and Scientific Research Projects Related to Prevention and Control of Coronavirus Disease 2019 (COVID-19) of China Medical University, No. 1210120010.
Institutional review board statement: This study was approved by the Medical Ethics Committee from Shengjing Hospital of China Medical University (reference number 2020PS065K).
Informed consent statement: Patients were not required to give informed consent to the study.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Corresponding author: Rui Zheng, MD, PhD, Chief Physician, Deputy Director, Doctor, Professor, Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. zhengr@sj-hospital.org
Received: September 22, 2020 Peer-review started: September 22, 2020 First decision: December 13, 2020 Revised: January 15, 2021 Accepted: February 11, 2021 Article in press: February 11, 2021 Published online: April 6, 2021 Processing time: 182 Days and 5.2 Hours
ARTICLE HIGHLIGHTS
Research background
Coronavirus disease 2019 (COVID-19) has spread rapidly to multiple countries, and the illness severity, the atypical clinical presentation, and lack of specific anti-viral treatment have posed a challenge for the diagnosis and treatment of COVID-19.
Research motivation
Understanding the epidemiological and clinical characteristics of COVID-19 cases in different geographical areas are essential to improve the prognosis of COVID-19 patients.
Research objectives
This study aimed to investigate the epidemiological and clinical characteristics and main therapeutic strategy for confirmed COVID-19 patients hospitalized in Liaoning Province, China.
Research methods
A total of 65 adult patients with confirmed COVID-19 were enrolled in this retrospective study from January 20 to February 29, 2020 in Liaoning Province, China. Based on the severity of COVID-19, the patients were divided into nonsevere and severe groups.
Research results
Compared with nonsevere patients (75.4%), severe patients (24.6%) had significantly lower lymphocyte counts, elevated levels of lactate dehydrogenase and C-reactive protein, and a longer median duration of viral shedding. The overall median viral shedding time was 19.5 d, and the longest was 53 d. Severe patients were more frequently treated with lopinavir/ritonavir, antibiotics, glucocorticoid therapy, immunoglobulin, thymosin, and oxygen support.
Research conclusions
Our findings may facilitate the identification of severe cases and inform clinical treatment and quarantine decisions regarding COVID-19 patients.
Research perspectives
The identification of severe cases with COVID-19 may help prevent poor outcomes, while the estimated duration of viral shedding may help inform quarantine decisions and prevent acute respiratory syndrome coronavirus 2 spread.
