Feng X, Cao JS, Chen MY, Zhang B, Juengpanich S, Hu JH, Topatana W, Li SJ, Shen JL, Xiao GY, Cai XJ, Yu H. Laparoscopic surgery for early gallbladder carcinoma: A systematic review and meta-analysis. World J Clin Cases 2020; 8(6): 1074-1086 [PMID: 32258078 DOI: 10.12998/wjcc.v8.i6.1074]
Corresponding Author of This Article
Hong Yu, FACS, MD, PhD, Doctor, Surgeon, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. 3195016@zju.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Xu Feng, Jia-Sheng Cao, Ming-Yu Chen, Bin Zhang, Sarun Juengpanich, Jia-Hao Hu, Win Topatana, Shi-Jie Li, Ji-Liang Shen, Xiu-Jun Cai, Hong Yu, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Guang-Yuan Xiao, Department of General Surgery, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing 314000, Zhejiang Province, China
Author contributions: Feng X, Cao JS, Chen MY, Zhang B, Cai XJ, and Yu H designed the study and collected the data; Juengpanich S, Hu JH, Topatana W, and Li SJ analyzed the data; all authors performed the study and wrote the paper.
Supported bythe Zhejiang Medical Health Science and Technology Project, No. 2016133597 and No. 2019321842; and Natural Science Foundation of Zhejiang Province, No. LQ18H160003.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hong Yu, FACS, MD, PhD, Doctor, Surgeon, Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. 3195016@zju.edu.cn
Received: December 29, 2019 Peer-review started: December 29, 2019 First decision: January 19, 2020 Revised: February 14, 2020 Accepted: February 28, 2020 Article in press: February 28, 2020 Published online: March 26, 2020 Processing time: 87 Days and 23.1 Hours
ARTICLE HIGHLIGHTS
Research background
There is still controversy as to whether laparoscopic surgery leads to a poor prognosis compared to the open approach for early gallbladder carcinoma (GBC).
Research motivation
The safety and feasibility of laparoscopic surgery compared with open surgery for early GBC are controversial.
Research objectives
To compare the currently available results of laparoscopic surgery compared with open surgery to confirm which is better for early GBC.
Research methods
We systematically reviewed the literature on laparoscopic surgery and open surgery, and included relevant studies for meta-analysis.
Research results
The results indicated no significant differences in the 1-, 3-, and 5-year overall survival, operation time, intraoperative blood loss, the number of lymph nodes resected, and postoperative complications between the laparoscopic and open surgery groups. However, patients who underwent laparoscopic surgery had a reduced length of hospital stay than those who underwent open surgery.
Research conclusions
Laparoscopic surgery is a safe and feasible alternative to open surgery with comparable 1-, 3-, and 5-year survival and operation-related outcomes in early GBC.
Research perspectives
More prospective studies should be performed due to the limited sample size and lack of recurrence data in this study.
