Zhao ZT, Li Y, Yuan HY, Ma FH, Song YM, Tian YT. Identification of key genes and pathways in gastric signet ring cell carcinoma based on transcriptome analysis. World J Clin Cases 2020; 8(4): 658-669 [PMID: 32149050 DOI: 10.12998/wjcc.v8.i4.658]
Corresponding Author of This Article
Yan-Tao Tian, MD, Professor, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. tyt67@163.com
Research Domain of This Article
Cell Biology
Article-Type of This Article
Clinical and Translational Research
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Zhao ZT, Li Y, Yuan HY, Ma FH, Song YM, Tian YT. Identification of key genes and pathways in gastric signet ring cell carcinoma based on transcriptome analysis. World J Clin Cases 2020; 8(4): 658-669 [PMID: 32149050 DOI: 10.12998/wjcc.v8.i4.658]
Zi-Tong Zhao, Hong-Yu Yuan, Yong-Mei Song, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Yang Li, Fu-Hai Ma, Yan-Tao Tian, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Zhao ZT and Li Y contributed equally to this work; Zhao ZT, Li Y, Yuan HY, Ma FH, Song YM, and Tian YT contributed to the design of the study and the writing of the manuscript; all the authors reviewed and approved the final version to be published.
Supported byNational Key R&D Program of China, No. 2018YFC1313101; Wu Jieping Medical Foundation, No. 320.6750.15276.
Institutional review board statement: This study was approved by the institutional review board of the National Cancer Center of China.
Informed consent statement: The institutional review board of the National Cancer Center of China waived informed consent due to the retrospective nature of this research.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Corresponding author: Yan-Tao Tian, MD, Professor, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. tyt67@163.com
Received: January 2, 2020 Peer-review started: January 2, 2020 First decision: January 19, 2020 Revised: January 20, 2020 Accepted: February 15, 2020 Article in press: February 15, 2020 Published online: February 26, 2020 Processing time: 55 Days and 8.4 Hours
ARTICLE HIGHLIGHTS
Research background
Gastric signet ring cell carcinoma (GSRCC) has the features of high invasiveness, rapid progression, and resistance to chemotherapy. However, systematic analyses of mRNAs have not yet been performed.
Research motivation
The exploration of the molecular mechanism of GSRCC is important to improve the recognition of GSRCC and find the effective therapeutics to raise the survival rate of patients.
Research objectives
Transcriptome sequencing and comprehensive analysis were performed to identify key mRNAs and signaling pathways in GSRCC.
Research methods
A transcriptome analysis of two GSRCC and two non-GSRCC samples was performed. Differentially expressed mRNAs and pathways were identified. The interactive relationships among the differential genes were mapped with the STRING database.
Research results
The enriched KEGG and PANTHER pathways for the differential genes included immune response pathways, metabolic pathways, and metastasis-associated pathways. MAGEA2, MAGEA2B, MAGEA3, MAGEA4, MAGEA6, MUC13, GUCA2A, FFAR4, REG1A, and REG1B were identified as hub genes in the protein-protein interaction network. The expression levels of MAGEA2, MAGEA3, MAGEA4, MAGEA6, and REG1B showed potential clinical value.
Research conclusions
The potential key genes and pathways of GSRCC have been identified. These hub genes and pathways could be diagnostic markers and therapeutic targets for GSRCC.
Research perspectives
MAGE-A family as a CTA family member may be the potential targets for GSRCC. More research should be conducted for exploration of the mechanisms involved.
