Wang L, He WB, Yu XM, Hu DL, Jiang H. Prolonged prothrombin time at admission predicts poor clinical outcome in COVID-19 patients. World J Clin Cases 2020; 8(19): 4370-4379 [PMID: 33083396 DOI: 10.12998/wjcc.v8.i19.4370]
Corresponding Author of This Article
Hong Jiang, MD, Chief Physician, Director, Full Professor, Department of Cardiology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, District of Wuchang, Wuhan 430060, Hubei Province, China. hong-jiang@whu.edu.cn
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Oct 6, 2020; 8(19): 4370-4379 Published online Oct 6, 2020. doi: 10.12998/wjcc.v8.i19.4370
Prolonged prothrombin time at admission predicts poor clinical outcome in COVID-19 patients
Lang Wang, Wen-Bo He, Xiao-Mei Yu, Da-Long Hu, Hong Jiang
Lang Wang, Wen-Bo He, Xiao-Mei Yu, Hong Jiang, Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Lang Wang, Wen-Bo He, Xiao-Mei Yu, Hong Jiang, Cardiovascular Research Institute, Wuhan University, Wuhan 430060, Hubei Province, China
Lang Wang, Wen-Bo He, Xiao-Mei Yu, Hong Jiang, Hubei Key Laboratory of Cardiology, Wuhan 430060, Hubei Province, China
Da-Long Hu, School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, Australia
Author contributions: Wang L and He WB drafted the manuscript; Jiang H and Wang L conceived the idea; Wang L, He WB and Yu XM reviewed the medical records and collected the data; Hu DL performed the statistical analysis and reviewed the manuscript; Jiang H reviewed the manuscript; All authors have read and approved the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 81570450 and No. 81900455.
Institutional review board statement: This study was reviewed and approved by the National Natural Science Foundation of China.
Informed consent statement: The National Natural Science Foundation of China waived the informed consent for this study.
Conflict-of-interest statement: There is no conflict of interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hong Jiang, MD, Chief Physician, Director, Full Professor, Department of Cardiology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, District of Wuchang, Wuhan 430060, Hubei Province, China. hong-jiang@whu.edu.cn
Received: April 28, 2020 Peer-review started: April 28, 2020 First decision: May 21, 2020 Revised: June 2, 2020 Accepted: September 8, 2020 Article in press: September 8, 2020 Published online: October 6, 2020 Processing time: 152 Days and 10.8 Hours
ARTICLE HIGHLIGHTS
Research background
Coronavirus disease 2019 (COVID-19) has been spreading rapidly around the world. The disease progressed extremely fast in some severe to critical patients.
Research motivation
Early identification of COVID-19 patients at high risk is important for improving the clinical practice and outcomes.
Research objectives
To investigate the abnormalities of coagulation parameters in the patients with COVID-19 and their prognostic values.
Research methods
A retrospective, single-center study included 213 patients. The coagulation parameters at admission were compared between the survivors and those who died. The prognostic values of coagulation disorders were analyzed with logistic regression.
Research results
Coagulation disorders were significantly more common in the patients who died with COVID-19 than the survivors. Prothrombin time (PT), concentration of fibrin degradation products, respiration rate and age were predictive factors for fatal outcomes. The fatality of patients with prolonged PT at admission was significantly higher than those with normal PT.
Research conclusions
Patients with prolonged PT at admission were faced with a much higher risk of death. Thus, clinicians should be aware of this and treat these patients with caution.
Research perspectives
Patients with prolonged prothrombin time at admission should be treated with caution as they faced a much higher risk of death. Coagulation disorders were significantly more common in the patients who died with COVID-19.
