Wei N, Liu MH, Song YH. Causal associations between gastroesophageal reflux disease and essential hypertension: A bidirectional Mendelian randomization study. World J Clin Cases 2024; 12(5): 880-890 [PMID: 38414595 DOI: 10.12998/wjcc.v12.i5.880]
Corresponding Author of This Article
Yu-Hu Song, MD, PhD, Professor, Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. yuhusong@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Clinical and Translational Research
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Wei N, Liu MH, Song YH. Causal associations between gastroesophageal reflux disease and essential hypertension: A bidirectional Mendelian randomization study. World J Clin Cases 2024; 12(5): 880-890 [PMID: 38414595 DOI: 10.12998/wjcc.v12.i5.880]
World J Clin Cases. Feb 16, 2024; 12(5): 880-890 Published online Feb 16, 2024. doi: 10.12998/wjcc.v12.i5.880
Causal associations between gastroesophageal reflux disease and essential hypertension: A bidirectional Mendelian randomization study
Ning Wei, Ming-Hui Liu, Yu-Hu Song
Ning Wei, Ming-Hui Liu, Yu-Hu Song, Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Author contributions: Song YH and Wei N concept of the study and grant obtain; Liu MH data analysis; Liu MH and Wei H preparation of manuscript; Song YH and Wei N administrative, technical, or material support; study supervision; all the authors read and approved the paper.
Supported byNational Natural Science Foundation of China (General Program), No. 82070631.
Institutional review board statement: We used publicly accessible GWAS summary data or published trial data for our analyses. For this manuscript, no original data were gathered, and no ethics committee permission was needed.
Clinical trial registration statement: We used publicly accessible GWAS summary data or published trial data for our analyses. For this manuscript, no original data were gathered, and no ethics committee permission was needed. The institutional ethics review committees for each of the included studies gave their approval, and all participants gave their written informed permission.
Informed consent statement: We used publicly accessible GWAS summary data or published trial data for our analyses. For this manuscript, no original data were gathered, and no ethics committee permission was needed. The institutional ethics review committees for each of the included studies gave their approval, and all participants gave their written informed permission.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
Corresponding author: Yu-Hu Song, MD, PhD, Professor, Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. yuhusong@163.com
Received: October 16, 2023 Peer-review started: October 16, 2023 First decision: November 28, 2023 Revised: December 12, 2023 Accepted: January 16, 2024 Article in press: January 16, 2024 Published online: February 16, 2024 Processing time: 106 Days and 19.5 Hours
ARTICLE HIGHLIGHTS
Research background
Some clinical studies have suggested that gastroesophageal reflux disease (GERD) may have a causal relationship with essential hypertension, but the relevant conclusions may be affected by confounding factors and small sample sizes.
Research motivation
Determining the causal relationship between GERD and essential hypertension could provide new perspectives for the treatment of patients with GERD and hypertension.
Research objectives
We would perform a bidirectional Mendelian randomization (MR) analysis to investigate the causal link between GERD and essential hypertension.
Research methods
A series of steps were conducted to select eligible single nucleotide polymorphisms, and inverse variance weighted (IVW), weighted median and MR egger regression were used to examine whether there was a causal association between GERD and hypertension.
Research results
IVW analysis exhibited an increased risk of hypertension (OR = 1.46, 95%CI: 1.33-1.59, P = 2.14E-16) in GERD patients. Meanwhile, the IVW analysis showed an increased risk of systolic blood pressure and hypertensive heart disease in GERD patients.
Research conclusions
GERD was positively associated with the risk of essential hypertension, suggesting a new prevent strategy and therapeutic perspectives of essential hypertension in patients with GERD.
Research perspectives
The specific mechanisms associated with GERD and essential hypertension need to be further clarified.
