Liu K, Li ZH. Efficacy and safety of Nafamostat mesylate in patients with end-stage renal failure. World J Clin Cases 2024; 12(1): 68-75 [PMID: 38292627 DOI: 10.12998/wjcc.v12.i1.68]
Corresponding Author of This Article
Zhen-Hua Li, MM, Chief Doctor, Department of Critical Care Medicine, General Hospital of The Yangtze River Shipping, Wuhan Brain Hospital, No. 5 Huiji Road, Wuhan 430015, Hubei Province, China. zhenh0911@163.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Liu K, Li ZH. Efficacy and safety of Nafamostat mesylate in patients with end-stage renal failure. World J Clin Cases 2024; 12(1): 68-75 [PMID: 38292627 DOI: 10.12998/wjcc.v12.i1.68]
World J Clin Cases. Jan 6, 2024; 12(1): 68-75 Published online Jan 6, 2024. doi: 10.12998/wjcc.v12.i1.68
Efficacy and safety of Nafamostat mesylate in patients with end-stage renal failure
Kun Liu, Zhen-Hua Li
Kun Liu, Department of Critical Care Medicine, The Third People's Hospital Of Hubei Province, Wuhan 430030, Hubei Province, China
Zhen-Hua Li, Department of Critical Care Medicine, General Hospital of The Yangtze River Shipping, Wuhan Brain Hospital, Wuhan 430015, Hubei Province, China
Co-first authors: Kun Liu and Zhen-Hua Li
Author contributions: Liu K and Li ZH designed the research; Liu K contributed new reagents/analytic tools; Liu K and Li ZH analyzed the data; Liu K and Li ZH wrote the paper. Liu K and Li Z has co-first authors are threefold. First, Liu K and Li ZH designed and conceptualized the study. Second, Liu K and Li ZH participated in discussion development and provided expert guidance. Third, Liu K and Li ZH put in the same effort throughout the study, and in summary, we believe that Li ZH can be tagged as co-first author in our manuscript.
Institutional review board statement: This study protocol was approved by the General Hospital of The Yangtze River Shipping, Wuhan Brain Hospital, and all the families have voluntarily participated in the study and have signed informed consent forms.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declared no conflict of interest existing in this paper.
Data sharing statement: Data generated from this investigation are available upon reasonable quest from the corresponding author.
Corresponding author: Zhen-Hua Li, MM, Chief Doctor, Department of Critical Care Medicine, General Hospital of The Yangtze River Shipping, Wuhan Brain Hospital, No. 5 Huiji Road, Wuhan 430015, Hubei Province, China. zhenh0911@163.com
Received: November 10, 2023 Peer-review started: November 10, 2023 First decision: November 22, 2023 Revised: December 5, 2023 Accepted: December 18, 2023 Article in press: December 18, 2023 Published online: January 6, 2024 Processing time: 53 Days and 4.9 Hours
ARTICLE HIGHLIGHTS
Research background
Recent studies on anticoagulation on dialysis in patients with renal failure suggest, Nafamostat mesylate, a broad-spectrum highly potent serine protease inhibitor with potent anticoagulation and antifibrous activity, with a significant anticoagulant effect.
Research motivation
In the early clinical stage of terminal renal failure, there are no obvious symptoms. With the progression of the disease, limb edema, fatigue, gastrointestinal bleeding and other symptoms gradually appear, and more serious and even consciousness disorders and cardiac arrest, seriously endangering the life of the patient.
Research objectives
Efficacy and safety of Nafamostat mesylate in patients with end-stage renal failure.
Research methods
It was divided into observation group and control group. The clinical efficacy indicators of the two groups were compared.
Research results
While the number of patients in grade 0 was lower in the control group, and the number of patients in grades II and III was higher in the control group (P < 0.05). The post-treatment prothrombin time, activated partial thromboplastin time, thrombin time, and international normalized ratio values in the control group were higher than those in the observation group.
Research conclusions
The use of Nafamostat mesylate in patients with end-stage renal failure can significantly improve the treatment effect and have high safety and clinical value.
Research perspectives
We discuss the efficacy and safety of Nafamostat mesylate in patients with end-stage renal failure.
