Haider MB, Basida B, Kaur J. Major depressive disorders in patients with inflammatory bowel disease and rheumatoid arthritis. World J Clin Cases 2023; 11(4): 764-779 [PMID: 36818627 DOI: 10.12998/wjcc.v11.i4.764]
Corresponding Author of This Article
Maryam Bilal Haider, MD, Doctor, Department of Internal Medicine, Detroit Medical Center, Wayne State University, Sinai Grace Hospital, 6071 Outer Dr W, Detroit, MI 48235, United States. maryambilalhaider@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 6, 2023; 11(4): 764-779 Published online Feb 6, 2023. doi: 10.12998/wjcc.v11.i4.764
Major depressive disorders in patients with inflammatory bowel disease and rheumatoid arthritis
Maryam Bilal Haider, Brinda Basida, Jasleen Kaur
Maryam Bilal Haider, Department of Internal Medicine, Detroit Medical Center, Wayne State University, Sinai Grace Hospital, Detroit, MI 48235, United States
Brinda Basida, Department of Geriatrics, Rohde Island Hospital/Brown University, Providence, RI 02903, United States
Jasleen Kaur, Department of Rheumatology, St. Mary’s Ascension/Central Michigan University, Saginaw, MI 48601, United States
Author contributions: Haider MB, Basida B and Kaur J contributed equally to this work; Haider MB and Kaur J designed the research study; Kaur J and Basida B performed the research; Haider MB analyzed the data; Haider MB, Basida B and Kaur J wrote the manuscript; All authors have read and approve the final manuscript.
Institutional review board statement: Data from this study used de-identified data from the National Inpatient Sample Database (NIS) 2000-2019. A publicly available all-payer inpatient care database in the United States. Institutional Review Board Approval Form or Document is not required.
Informed consent statement: Data from this study used de-identified data from the National Inpatient Sample Database. A publicly available all-payer inpatient care database in the United States. Informed patient consent is not required.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Maryam Bilal Haider, MD, Doctor, Department of Internal Medicine, Detroit Medical Center, Wayne State University, Sinai Grace Hospital, 6071 Outer Dr W, Detroit, MI 48235, United States. maryambilalhaider@yahoo.com
Received: September 21, 2022 Peer-review started: September 21, 2022 First decision: November 30, 2022 Revised: December 14, 2022 Accepted: January 12, 2023 Article in press: January 12, 2023 Published online: February 6, 2023 Processing time: 137 Days and 18.9 Hours
ARTICLE HIGHLIGHTS
Research background
Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA), are found to have a substantial societal burden, increased healthcare costs, and progressive disability. Studies suggest that patients with vs without depression have a more significant disability, a lower likelihood of remission, and reduced adherence to therapy.
Research motivation
The role of the Brain-Gut axis and Brain-Joint axis in the development of depression has been discussed, but there is not enough literature demonstrating the combined Brain-Gut-Joint axis.
Research objectives
Our primary aim is to identify a pooled prevalence level and temporal trends of depression in hospitalized IBD-RA patients. We aimed to investigate clinical factors associated with depression in these patients.
Research methods
All adult hospitalized patients from January 2000 to December 2019 in the nationwide inpatient sample were captured. The study population included all patients with a primary or secondary IBD-RA overlap disease using corresponding international classification of diseases (ICD)-9 and ICD-10 codes.
Research results
Other factors associated with higher major depressive disorder included younger age, female gender, white race, alcohol, opioids, esophageal disorders, peptic ulcer disease, chronic pancreatitis, paralysis, dementia, menopausal disorders, obesity, nutritional deficiencies, diabetes mellitus with chronic complications, and osteoarthritis.
Research conclusions
There is an inevitable rise in the prevalence of depression in younger patients with IBD-RA combined autoimmune diseases. As physicians, we can play an important role in social determinants of health by giving good quality care. Timely recognition of depression in these patients is critical to preventing disability.
Research perspectives
Our study discusses the clinical data on this combined axis and emphasizes potentially valuable strategies for managing these patients. This study will open the door for further research and educate the involved physicians to identify the early signs and symptoms of depression in patients with IBD or RA or IBD-RA combined and treat them or have them treated to have a better overall prognosis.
