Clinical implications of forkhead box M1, cyclooxygenase-2, and glucose-regulated protein 78 in breast invasive ductal carcinoma

ARTICLE HIGHLIGHTS

Research background

Breast infiltrating ductal carcinoma (BIDC) represents the largest heterotypic tumor group, and this study analyzed the clinical significance of forkhead box M1 (FOXM1), cyclooxygenase-2 (COX-2), and glucose-regulated protein 78 (GRP78) in BIDC, which could provide a reliable foundation for subsequent studies.

Research motivation

FOXM1, COX-2, and GRP78 are closely related to breast cancer development and progression, but their roles in BIDC remain unclear. They may play equally important roles and hold promise for future diagnosis and treatment of BIDC.

Research objectives

To analyze the clinical significance of FOXM1, COX-2, and GRP78 in BIDC, and to provide references and new research directions for future diagnosis and treatment of BIDC.

Research methods

In this study, we analyzed the clinical significance of FOXM1, COX-2, and GRP78 in BIDC by detecting the expression levels of FOXM1, COX-2, and GRP78 in the peripheral blood of patients with BIDC and healthy people.

Research results

FOXM1, COX-2, and GRP78 were elevated in BIDC and demonstrated excellent diagnostic and prognostic assessment of BIDC.

Research conclusions

FOXM1, COX-2, and GRP78 exhibit abnormally high expression in BIDC, promoting malignant tumor development and closely correlating with prognosis.

Research perspectives

This study demonstrated the clinical significance of FOXM1, COX-2, and GRP78 in BIDC, and in the future, they can be used in the clinic as reference indexes for the diagnosis, disease evaluation, and prognosis assessment of BIDC. In addition, they can also be used as targets to study new targeted therapeutic options for BIDC in the future.