Published online May 26, 2023. doi: 10.12998/wjcc.v11.i15.3511
Peer-review started: February 7, 2023
First decision: February 28, 2023
Revised: March 6, 2023
Accepted: April 6, 2023
Article in press: April 6, 2023
Published online: May 26, 2023
Processing time: 107 Days and 6.8 Hours
Sepsis is one of the main causes of death in the intensive care unit and hospitals. Sepsis patients often have heart failure. However, the impact of heart failure on the mortality of sepsis patients is controversial.
Although the treatment of sepsis has been updated, the effect of heart failure on the outcome of patients with sepsis still requires further study. Understanding whether heart failure, as a comorbidity, will affect the survival of patients with sepsis is significant in order to take appropriate measures to reduce the occurrence of adverse results.
The purpose of our study was to assess whether heart failure increases the mortality of patients with sepsis by collecting existing research evidence.
PubMed, Embase, Web of Science, and Cochrane Library databases from inception to November 9, 2022 were searched to compare the prognosis of sepsis patients with heart failure. The outcome data were summarized in the random effect model using odds ratio (OR) and 95% confidence interval (CI).
Ten studies were included. The results showed that sepsis patients with heart failure were associated with increased total mortality (OR = 1.80, 95%CI: 1.34-2.43; I2 = 92.1%). Heart failure did not increase the 1-year mortality of patients (OR = 1.11, 95%CI: 0.75-1.62; I2 = 93.2%), and the mortality of patients with isolated right ventricular dysfunction (OR = 2.32, 95%CI: 1.29-4.14; I2 = 91.5%) increased significantly.
Contemporary evidence indicates that heart failure significantly increases the risk of death in patients with sepsis, especially right ventricular dysfunction.
Sepsis patients with heart failure should receive highly monitored treatment, and more high-quality related research is needed.