Published online Mar 26, 2022. doi: 10.12998/wjcc.v10.i9.2801
Peer-review started: September 22, 2021
First decision: December 10, 2021
Revised: December 23, 2021
Accepted: February 15, 2022
Article in press: February 15, 2022
Published online: March 26, 2022
Processing time: 180 Days and 23.8 Hours
Bone grafts have been widely applied in orthopedic surgery, but their efficacy in relation to bone regeneration in jaw cystic lesions remains unclear.
To identify whether bone grafts are beneficial for bone regeneration in jaw cystic lesions and when bone grafts should be used.
To study the level of bone regeneration after bone grafting compared to spontaneous healing in the treatment of jaw cystic lesions.
A literature search was performed in Medline, Cochrane Library and Embase to identify related articles published in English in the last ten years. Articles without assessment of bone regeneration or uniform follow-up time were excluded. Case reports, clinical trials, clinical studies, observational studies and randomized controlled trials were included.
Ten studies were included. Over 90% of bone regeneration occurred within 6 mo after bone grafting. The bone regeneration rate after cystectomy ranged from 50% to 100% after 6 mo, but reached over 90% after 12 mo.
Bone grafts accelerate the process of healing and significantly increase bone quality, but the long-term superiority of bone grafting compared with spontaneous healing after cystectomy is unclear.
There is a need for future studies with better assessment methods, variable control and strict randomized design, as well as longer follow-up time.