Al-Dadah O, Shepstone L, Donell ST. Patient reported outcome measures in anterior cruciate ligament rupture and reconstruction: The significance of outcome score prediction. World J Clin Cases 2022; 10(30): 10939-10955 [PMID: 36338237 DOI: 10.12998/wjcc.v10.i30.10939]
Corresponding Author of This Article
Oday Al-Dadah, FRCS, MBChB, MD, Senior Lecturer, Surgeon, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, Tyne and Wear, United Kingdom. oday.al-dadah@newcastle.ac.uk
Research Domain of This Article
Orthopedics
Article-Type of This Article
Prospective Study
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Al-Dadah O, Shepstone L, Donell ST. Patient reported outcome measures in anterior cruciate ligament rupture and reconstruction: The significance of outcome score prediction. World J Clin Cases 2022; 10(30): 10939-10955 [PMID: 36338237 DOI: 10.12998/wjcc.v10.i30.10939]
World J Clin Cases. Oct 26, 2022; 10(30): 10939-10955 Published online Oct 26, 2022. doi: 10.12998/wjcc.v10.i30.10939
Patient reported outcome measures in anterior cruciate ligament rupture and reconstruction: The significance of outcome score prediction
Oday Al-Dadah, Lee Shepstone, Simon T Donell
Oday Al-Dadah, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne NE2 4HH, Tyne and Wear, United Kingdom
Oday Al-Dadah, Department of Trauma and Orthopaedic Surgery, South Tyneside District Hospital, South Shields NE34 0PL, Tyne and Wear, United Kingdom
Lee Shepstone, Department of Medical Statistics, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, Norfolk, United Kingdom
Simon T Donell, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, Norfolk, United Kingdom
Author contributions: Al-Dadah O made substantial contributions to conception and design of the study and acquisition of data; He also performed the analysis and interpretation of data; Has been involved in drafting the manuscript and revising it critically for important intellectual content; Has given final approval of the version to be published; Shepstone L made substantial contributions to conception and design of the study; He also made substantial contributions to the analysis and interpretation of data; Has been involved in drafting the manuscript and revising it critically for important intellectual content; Has given final approval of the version to be published; Donell ST made substantial contributions to conception and design of the study; He also made substantial contributions to the interpretation of data; Has been involved in drafting the manuscript and revising it critically for important intellectual content; Has given final approval of the version to be published.
Institutional review board statement: Full approval was received for the study from the Research Ethics Committee and the Research Governance Committee. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee [East Norfolk and Waveney Research Governance Committee, United Kingdom (ID 116/07/07)] and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Clinical trial registration statement: This study was not registered on any trial registry.
Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare that they have no conflict of interest.
Data sharing statement: The data underlying this article cannot be shared publicly due to the privacy of individuals that participated in the study and in keeping with the United Kingdom General Data Protection Regulation and also the host study organization’s patient confidentiality guidelines.
CONSORT 2010 statement: The authors have read the CONSORT Statement—checklist of items, and the manuscript was prepared and revised according to the CONSORT Statement—checklist of items.
Corresponding author: Oday Al-Dadah, FRCS, MBChB, MD, Senior Lecturer, Surgeon, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle-upon-Tyne NE2 4HH, Tyne and Wear, United Kingdom. oday.al-dadah@newcastle.ac.uk
Received: February 13, 2022 Peer-review started: February 13, 2022 First decision: June 15, 2022 Revised: July 5, 2022 Accepted: September 19, 2022 Article in press: September 19, 2022 Published online: October 26, 2022 Processing time: 249 Days and 5.2 Hours
ARTICLE HIGHLIGHTS
Research background
Many different types of clinical outcome scores exist regarding the anterior cruciate ligament (ACL).
Research motivation
To evaluate how the commonly used patient reported outcome scores (PROMs) differ from each other in the context of ACL injuries.
Research objectives
To develop mathematical formulae which will allow the results of one score to be calculated from the results of the other.
Research methods
PROM data was collected from patients before and after ACL reconstruction surgery and statistically analyzed using correlation and regression tests.
Research results
Statistically significant results for both the correlation and regression analyses were found between most of the outcome scores and were generally stronger following surgery.
Research conclusions
The mathematical formulae produced from this study can be used to predict the outcome of one knee score when the results of the other are known.
Research perspectives
These mathematical formulae can facilitate the conduct of systematic reviews and meta-analysis in studies relating to ACL surgery by allowing the pooling of substantially more data.
