Published online Oct 6, 2022. doi: 10.12998/wjcc.v10.i28.10109
Peer-review started: May 30, 2022
First decision: July 14, 2022
Revised: July 20, 2022
Accepted: September 1, 2022
Article in press: September 1, 2022
Published online: October 6, 2022
Processing time: 119 Days and 23.9 Hours
Coronavirus disease 2019 (COVID-19) was first identified November 2019 and subsequently caused a world pandemic. The development of vaccines was quickly achieved with the first vaccinations occurring in December 2020. From then on, a global campaign commenced to vaccinate the majority of the world’s population. The implications of these vaccines have been researched abundantly.
The side effects of COVID-19 vaccines, particularly serious cardiovascular side effects, mention myocarditis. However, myocardial infarction (MI) and its link with COVID-19 vaccines remain unclear.
To investigate and pinpoint if any link exists between COVID-19 vaccination and MI amongst the vaccinated individuals.
We devised a search strategy to search MEDLINE, EMBASE, and PakMediNet. All studies that reported MI after COVID-19 vaccine delivery were included in this research. A structured data extraction form was developed to extract the data from the eligible studies.
The majority of MI cases reported were after vaccination with the AstraZeneca vaccine. Out of all the studies, 69% reported MI cases after the first COVID-19 vaccination dose and 14% after the second. The majority (44%) of MI reported was STEMI.
Many studies linked MI to COVID-19 vaccinations, but no definitive association could be found.
More robust clinical trials in this regard could clarify the link between COVID-19 vaccinations and MI.