Ren MY, Li J, Wu YX, Li RM, Zhang C, Liu LM, Wang JJ, Gao Y. Clinical characteristics and prognosis of orbital solitary fibrous tumor in patients from a Chinese tertiary eye hospital. World J Clin Cases 2022; 10(27): 9670-9679 [PMID: 36186212 DOI: 10.12998/wjcc.v10.i27.9670]
Corresponding Author of This Article
Ming-Yu Ren, MMed, Associate Chief Physician, Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, No. 399 Quanbeidong, Xingtai 054001, Hebei Province, China. 147237583@qq.com
Research Domain of This Article
Ophthalmology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ming-Yu Ren, Yi-Xiang Wu, Rui-Miao Li, Li-Min Liu, Jing-Jing Wang, Yu Gao, Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, Xingtai 054001, Hebei Province, China
Jing Li, Intensive Care Unit, Xingtai Third Hospital, Xingtai 054001, Hebei Province, China
Chi Zhang, Department of Medical Imaging, Hebei Eye Hospital, Xingtai 054001, Hebei Province, China
Author contributions: Ren MY and Li J performed the research and wrote the paper; Ren MY and Li RM designed the research and supervised the report; Ren MY and Liu LM designed the research and contributed to the analysis; Wang JJ, Zhang C, and Gao Y provided clinical advice; Ren MY and Li J supervised the report; all authors revised the paper and approved the final version for submission.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Hebei Eye Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors have no financial relationships to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at 147237583@qq.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Yu Ren, MMed, Associate Chief Physician, Department of Orbital Disease and Ocular Tumor, Hebei Eye Hospital, No. 399 Quanbeidong, Xingtai 054001, Hebei Province, China. 147237583@qq.com
Received: May 27, 2022 Peer-review started: May 27, 2022 First decision: June 27, 2022 Revised: July 5, 2022 Accepted: August 21, 2022 Article in press: August 21, 2022 Published online: September 26, 2022 Processing time: 112 Days and 4.6 Hours
ARTICLE HIGHLIGHTS
Research background
Solitary fibrous tumor (SFT) is predominant within the pleura but very rare in the orbit, which is why the diagnosis of orbital SFT poses challenges in clinical practice.
Research motivation
Unspecific symptoms and a wide range of clinical manifestations of SFT can significantly hamper the establishment of a definitive diagnosis and treatment.
Research objectives
To retrospectively explore the clinical and imaging characteristics, treatment, outcomes of a series of patients with orbital SFT.
Research methods
This is a retrospective analysis of patients diagnosed with a histopathologic orbital SFT treated at a single institution. All data on demographics, clinical characteristics, imaging, treatment, postoperative histopathological and immunohistochemical (IHC) examinations, and prognosis were collected.
Research results
In total, 13 patients were enrolled, 7 (53.8%) of whom had the tumors located in the superomedial quadrant of the orbit. Notably, 12 (92.3%) patients showed significant enhancement, whereas there were patchy slightly enhanced areas in the tumor. IHC analysis demonstrated that the tumor cells were immunoreactive for CD34, CD99, STAT-6, and vimentin in all patients. The lesions showed Ki-67 positivity < 5% in 1 (7.7) patient, 5%-10% in 10 (76.9%), and > 10% in 2 (15.4%). Two (15.4%) patients exhibited tumor recurrence.
Research conclusions
The clinical manifestations and radiologic characteristics of orbital SFT are diverse and not specific. Accurate diagnosis and treatment require detailed radiological and histopathological/IHC evaluation.
Research perspectives
A more comprehensive analysis of the clinical symptoms, therapeutic efficacy, and prognosis of orbital SFT should be performed in the future.
