Miwa T, Kanemaru SI. Effects of Kampo medicine hangebyakujutsutemmato on persistent postural-perceptual dizziness: A retrospective pilot study. World J Clin Cases 2022; 10(20): 6811-6824 [PMID: 36051127 DOI: 10.12998/wjcc.v10.i20.6811]
Corresponding Author of This Article
Toru Miwa, MD, PhD, Neurosurgeon, Research Scientist, Department of Otolaryngology-Head and Neck Surgery, Osaka Metropolitan University, 1-4-3 Asahi-cho, Abeno-ku, Osaka 5458585, Japan. miw.com1101@gmail.com
Research Domain of This Article
Otorhinolaryngology
Article-Type of This Article
Retrospective Cohort Study
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Miwa T, Kanemaru SI. Effects of Kampo medicine hangebyakujutsutemmato on persistent postural-perceptual dizziness: A retrospective pilot study. World J Clin Cases 2022; 10(20): 6811-6824 [PMID: 36051127 DOI: 10.12998/wjcc.v10.i20.6811]
World J Clin Cases. Jul 16, 2022; 10(20): 6811-6824 Published online Jul 16, 2022. doi: 10.12998/wjcc.v10.i20.6811
Effects of Kampo medicine hangebyakujutsutemmato on persistent postural-perceptual dizziness: A retrospective pilot study
Toru Miwa, Shin-ichi Kanemaru
Toru Miwa, Department of Otolaryngology-Head and Neck Surgery, Osaka Metropolitan University, Osaka 5458585, Japan
Toru Miwa, Shin-ichi Kanemaru, Department of Otolaryngology-Head and Neck Surgery, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka 5308480, Japan
Toru Miwa, Shin-ichi Kanemaru, Department of Otolaryngology-Head and Neck Surgery, Kyoto University, Kyoto 7507501, Japan
Author contributions: Miwa T contributed to the investigation, project administration, methodology, software, resources, visualization, writing–original draft, data curation, formal analysis, supervision, conceptualization, validation, writing–review and editing; Kanemaru SI contributed to the methodology, supervision, conceptualization; All authors approved the final version of the manuscript.
Institutional review board statement: The study was conducted in accordance with the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of Kitano Hospital (protocol code 2104002 for the approval).
Informed consent statement: Written informed consent was obtained from all participants prior to study inclusion.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: The data are available upon reasonable request from the corresponding author.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Corresponding author: Toru Miwa, MD, PhD, Neurosurgeon, Research Scientist, Department of Otolaryngology-Head and Neck Surgery, Osaka Metropolitan University, 1-4-3 Asahi-cho, Abeno-ku, Osaka 5458585, Japan. miw.com1101@gmail.com
Received: January 13, 2022 Peer-review started: January 13, 2022 First decision: March 16, 2022 Revised: March 17, 2022 Accepted: April 22, 2022 Article in press: April 22, 2022 Published online: July 16, 2022 Processing time: 172 Days and 20.3 Hours
ARTICLE HIGHLIGHTS
Research background
Persistent postural-perceptual dizziness (PPPD) is characterized by a shift in processing spatial orientation information to favor visual or somatosensory information over vestibular inputs as well as failure of higher cortical mechanisms.
Research motivation
To date, no potential therapies for PPPD have been evaluated in randomized controlled clinical trials or been approved as a cure for this condition. Hangebyakujututemmato (HBT) has been reported as a potential treatment for PPPD.
Research objectives
Our aim was to examine the efficacy of HBT in PPPD.
Research methods
Patients were administered HBT extract (7.5 g/day), or not, for 3 mo. Assessments such as equilibrium tests were performed at baseline and every month after the start of the study. Multivariate regression analysis was performed to identify HBT responders.
Research results
The Kampo medicine, HBT, was effective as an adjunctive therapy for PPPD. In addition, HBT responders had autonomic dysfunction, unstable balance, semicircular canal paresis, anxiety, and poor sleep quality at baseline.
Research conclusions
HBT may be an effective adjunct treatment for PPPD. We identified the characteristics of the HBT responders.
Research perspectives
According to our results, and previous reports, several herbal ingredients in HBT might improve autonomic function and the cyclic AMP response element binding protein/the brain-derived neurotrophic factor pathway, resulting in sensory reweighting to establish a balance between the systems involved in PPPD.
