Zhou X, Wang DY, Ding CY, Liu H, Sun ZQ. Psychosocial adaptation and influencing factors among patients with chemotherapy-induced peripheral neuropathy. World J Clin Cases 2022; 10(15): 4843-4855 [PMID: 35801039 DOI: 10.12998/wjcc.v10.i15.4843]
Corresponding Author of This Article
Zhi-Qin Sun, MM, RN, Dean, Professor, Department of Nursing, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Gehu Street, Changzhou 213000, Jiangsu Province, China. zqs1201@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Cai-Yan Ding, Zhi-Qin Sun, Department of Nursing, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou 213000, Jiangsu Province, China
Hui Liu, School of Nursing, Bengbu Medical College, Bengbu 233000, Jiangsu Province, China
Author contributions: Zhou X and Wang DY contributed equally to this work; Zhou X and Sun ZQ designed the research study; Zhou X, Ding CY, Liu H performed the research; Zhou X and Wang DY contributed new reagents and analytic tools; Zhou X, Wang DY, Ding CY analyzed the data and wrote the manuscript; All the authors have read and approved the manuscript.
Supported bythe Nursing Research Project Funding by the Affiliated Changzhou Second People's Hospital of Nanjing Medical University, No. 2020HZD003.
Institutional review board statement: The study was reviewed and approved by the Science and Research Office of Changzhou Second People’s Hospital (Changzhou).
Conflict-of-interest statement: The authors declared that no conflict of interest.
Data sharing statement: No data available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Qin Sun, MM, RN, Dean, Professor, Department of Nursing, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Gehu Street, Changzhou 213000, Jiangsu Province, China. zqs1201@163.com
Received: December 11, 2021 Peer-review started: December 11, 2021 First decision: January 26, 2022 Revised: February 3, 2022 Accepted: March 27, 2022 Article in press: March 27, 2022 Published online: May 26, 2022 Processing time: 163 Days and 22.5 Hours
ARTICLE HIGHLIGHTS
Research background
Currently, the prevention and management of patients with chemotherapy-induced peripheral neuropathy (CIPN) are mostly focused on enhancing physical adaptation, and there is a lack of psychosocial adaptation.
Research motivation
To investigate the current situation of psychosocial adaptation to the disease and its influencing factor in patients with CIPN.
Research objectives
A total of 233 patients hospitalized with CIPN were enrolled according to the relevant inclusion and exclusion criteria.
Research methods
A cross-sectional survey was conducted using a sociodemographic questionnaire, the Self-Report Psychosocial Adjustment to Illness Scale, and the European Organisation for the Research and Treatment of Cancer Quality of Life CIPN20 (QLQ-CIPN20). The influencing factors of psychosocial adaptation in patients with CIPN were analyzed by t-test or one-way analysis of variance, correlation analysis, multiple stepwise regression analysis, and structural equation models.
Research results
The psychosocial adaptation score of patients with CIPN was 52.51 ± 13.18. Multivariate analysis results showed that autonomic nerves, tumor stage, motor nerves, education level, with caregivers, being semi-retired, and CIPN grade were independent risk factors for patients with CIPN. Structural equation models showed that QLQ-CIPN20 mediated the relationship between CIPN grade, tumor stage, and psychosocial adaptation.
Research conclusions
Patients with CIPN have a poor level of psychosocial adaptation and are affected by a variety of physical, psychological, and social factors.
Research perspectives
To provide a reference for future psychosocial adaptation interventions with the aim of improving the overall level of psychological adaptation.
