Washed microbiota transplantation reduces serum uric acid levels in patients with hyperuricaemia

doi:10.12998/wjcc.v10.i11.3401

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World Journal of Clinical Cases

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World J Clin Cases. Apr 16, 2022; 10(11): 3401-3413
Published online Apr 16, 2022. doi: 10.12998/wjcc.v10.i11.3401

Washed microbiota transplantation reduces serum uric acid levels in patients with hyperuricaemia

Jin-Rong Cai, Xin-Wen Chen, Yu-Jian He, Bin Wu, Min Zhang, Li-Hao Wu

Jin-Rong Cai, Xin-Wen Chen, Yu-Jian He, Bin Wu, School of Clinical Medicine, Guangdong Pharmaceutical University, Guangzhou 510030, Guangdong Province, China

Min Zhang, Department of Epidemiology and Health Statistics, Guangdong Pharmaceutical University, Guangzhou 510220, Guangdong Province, China

Li-Hao Wu, Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510030, Guangdong Province, China

Li-Hao Wu, Research Center, Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province, Guangzhou 510030, Guangdong Province, China

Author contributions: Cai JR, Chen XW, He YJ and Wu B jointly analysed the data, wrote the manuscript, and contributed equally to this article; Zhang M provided statistical advice; Wu LH designed the study and revised the manuscript; all authors read and approved the manuscript.

Supported by the Innovation and Entrepreneurship Training Program for College Students of Guangdong Province, No. S201910573028.

Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Guangdong Pharmaceutical University, No. 68.

Informed consent statement: All participants signed written informed consent.

Conflict-of-interest statement: We have no financial relationships to disclose.

Data sharing statement: No additional data are available.

Corresponding author: Li-Hao Wu, MD, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Guangdong Pharmaceutical University, No. 19 Nonglinxia Road, Yuexiu District, Guangzhou 510030, Guangdong Province, China. wulihao888@126.com

Received: October 27, 2021
Peer-review started: October 27, 2021
First decision: December 27, 2021
Revised: January 8, 2022
Accepted: February 17, 2022
Article in press: February 27, 2022
Published online: April 16, 2022
Processing time: 163 Days and 1 Hours

ARTICLE HIGHLIGHTS

Research background

Hyperuricaemia (HUA) pathogenesis is closely associated with intestinal bacteria.

Research motivation

Current treatments for HUA have failed to obtained satisfactory clinical results.

Research objectives

To investigate the effect and safety of washed microbiota transplantation (WMT) on serum uric acid (SUA) levels in different populations.

Research methods

A total of 144 patients who received WMT from July 2016 to April 2020 in the First Affiliated Hospital of Guangdong Pharmaceutical University and had SUA data before treatment were selected. The changes in SUA levels before and after treatment were retrospectively reviewed. According to the pretreatment SUA level, the patients were divided into a hyperuricaemia group (HUA group: SUA > 416 μM) and a normal uric acid group (NUA group: SUA ≥ 202 μM to ≤ 416 μM). Statistical product and service solutions 26.0 was used to analyse the data.

Research results

The average short-term SUA levels in the HUA group decreased after WMT (481.00 ± 99.85 vs 546.81 ± 109.64 μM, n = 32, P < 0.05). The levels decreased in 25/32 patients and returned to normal in 10/32 patients. The short-term level of SUA reduction after treatment moderately correlated with the SUA levels before treatment (r = 0.549, R² = 0.300, P < 0.05). The average SUA levels decreased after the first and second courses of WMT (469.74 ± 97.68 vs 540.00 ± 107.16 μM, n = 35, 465.57 ± 88.88 vs 513.19 ± 78.14 μM, n = 21, P < 0.05). Short-term and mid-term SUA levels in the NUA group after WMT and SUA levels after the first, second and third courses of WMT were similar to those before WMT (P > 0.05). Only 1/144 patients developed mild diarrhoea after WMT.

Research conclusions

WMT can lower the SUA level in patients with HUA in the short term with mild side effects, but WMT has no obvious effect on the SUA level of patients with NUA.

Research perspectives

WMT may be a novel treatment for HUA.