Published online Jan 7, 2022. doi: 10.12998/wjcc.v10.i1.136
Peer-review started: July 4, 2021
First decision: October 18, 2021
Revised: October 28, 2021
Accepted: November 28, 2021
Article in press: November 28, 2021
Published online: January 7, 2022
Processing time: 179 Days and 1.1 Hours
The pathogenesis of colonic diverticulosis is not well understood.
Only a few studies on colonic diverticulosis have been reported in mainland China. Understanding the true prevalence of colonic diverticulosis and the risk factors associated with it will aid in the prevention and treatment of this disease.
To evaluate the prevalence of and risk factors for asymptomatic colorectal diverticulosis in mainland China.
From August 2016 to July 2020, 6180 asymptomatic individuals were enrolled in this cross-sectional study.
Logistic regression analysis revealed that an age ≥ 60 years (adjusted odds ratio [OR] 2.149, 95% confidence interval [CI] 1.511-3.057, P < 0.001), male sex (adjusted OR: 1.878, 95%CI: 1.373-2.568, P < 0.001), obesity (adjusted OR: 1.446, 95%CI: 1.100-1.902, P = 0.008), alcohol intake (adjusted OR: 1.518, 95%CI: 1.213-1.901, P < 0.001), hypertension (adjusted OR: 1.454, 95%CI: 1.181-1.789, P < 0.001), hypertriglyceridemia (adjusted OR: 1.287, 95%CI: 1.032-1.607, P = 0.025), and hyperuricemia (adjusted OR: 1.570, 95%CI: 1.257-1.961, P < 0.001) significantly increased the risk of colonic diverticulosis.
Advanced age, male sex, alcohol intake, obesity, and other metabolic-related factors, such as hypertension, hypertriglyceridemia, and hyperuricemia, were independent risk factors for colonic diverticulosis.
Our findings are of educative value and are likely to aid clinicians in the management of patients with this disease entity.