Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10645
Peer-review started: January 7, 2021
First decision: July 16, 2021
Revised: July 17, 2021
Accepted: October 20, 2021
Article in press: October 20, 2021
Published online: December 6, 2021
Processing time: 327 Days and 5 Hours
Pemphigoid gestationis (PG) is a rare autoimmune blistering disease that usually presents in the second or third trimester, with an incidence of 1 per 50000 pregnancies. PG tends to recur with an earlier onset and a more severe course in subsequent pregnancies. Skin biopsy markers can be confirmed by direct immunofluorescence staining.
Our patient was diagnosed with PG at 8 mo of gestation with fresh bullous lesion marks on the abdomen and limbs. Termination of the pregnancy was performed by cesarean section at 37 + 4 wk of gestation. The patient delivered an infant weighing 3620 gm. The infant had urticaria-like and vesicular skin lesions and was diagnosed with PG. The patient was discharged on prednisolone and in a satisfactory condition. The infant was discharged after anti-inflammatory therapy for one week.
PG is a rarely reported disease, and 10% of newborns develop mild clinical symptoms consisting of urticaria-like or vesicular skin lesions. We intend to remind clinicians to consider this condition when a patient presents with such lesions so that treatment can be started early and neonatal morbidity can be taken into account.
Core Tip: Pemphigoid gestationis (PG) is a rarely reported disease, and 10% of newborns develop mild clinical symptoms consisting of urticaria-like or vesicular skin lesions. Our patient was diagnosed with PG at 8 mo of gestation and was performed by cesarean section at 37 + 4 wk of gestation. The infant had urticaria-like and vesicular skin lesions and was diagnosed with PG. We intend to remind clinicians to consider this condition when a patient presents with such lesions so that treatment can be started early and neonatal morbidity can be taken into account.