Jiao HN, Ruan YP, Liu Y, Pan M, Zhong HP. Diagnosis, fetal risk and treatment of pemphigoid gestationis in pregnancy: A case report. World J Clin Cases 2021; 9(34): 10645-10651 [PMID: 35004996 DOI: 10.12998/wjcc.v9.i34.10645]
Corresponding Author of This Article
Hui-Ping Zhong, MD, Professor, Chief Doctor, Department of Obstetrics and Gynecology, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Rui-Jin 2nd Road, Huangpu District, Shanghai, 200025, China. zhp10392@rjh.com.cn
Research Domain of This Article
Obstetrics & Gynecology
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Case Report
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Jiao HN, Ruan YP, Liu Y, Pan M, Zhong HP. Diagnosis, fetal risk and treatment of pemphigoid gestationis in pregnancy: A case report. World J Clin Cases 2021; 9(34): 10645-10651 [PMID: 35004996 DOI: 10.12998/wjcc.v9.i34.10645]
World J Clin Cases. Dec 6, 2021; 9(34): 10645-10651 Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10645
Diagnosis, fetal risk and treatment of pemphigoid gestationis in pregnancy: A case report
Hai-Ning Jiao, Ye-Ping Ruan, Yan Liu, Meng Pan, Hui-Ping Zhong
Hai-Ning Jiao, Yan Liu, Hui-Ping Zhong, Department of Obstetrics and Gynecology, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Ye-Ping Ruan, Meng Pan, Department of Dermatology, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Author contributions: Jiao HN, Ruan YP and Zhong HP contributed to the planning, conduction and report of the work; Jiao HN, Ruan YP, Pan M and Zhong HP contributed to the conception and design of the work; Jiao HN, Liu Y and Zhong HP contributed to the acquisition of analysis and interpretation of the results; all authors have read and approved the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui-Ping Zhong, MD, Professor, Chief Doctor, Department of Obstetrics and Gynecology, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Rui-Jin 2nd Road, Huangpu District, Shanghai, 200025, China. zhp10392@rjh.com.cn
Received: January 7, 2021 Peer-review started: January 7, 2021 First decision: July 16, 2021 Revised: July 17, 2021 Accepted: October 20, 2021 Article in press: October 20, 2021 Published online: December 6, 2021 Processing time: 327 Days and 5 Hours
Abstract
BACKGROUND
Pemphigoid gestationis (PG) is a rare autoimmune blistering disease that usually presents in the second or third trimester, with an incidence of 1 per 50000 pregnancies. PG tends to recur with an earlier onset and a more severe course in subsequent pregnancies. Skin biopsy markers can be confirmed by direct immunofluorescence staining.
CASE SUMMARY
Our patient was diagnosed with PG at 8 mo of gestation with fresh bullous lesion marks on the abdomen and limbs. Termination of the pregnancy was performed by cesarean section at 37 + 4 wk of gestation. The patient delivered an infant weighing 3620 gm. The infant had urticaria-like and vesicular skin lesions and was diagnosed with PG. The patient was discharged on prednisolone and in a satisfactory condition. The infant was discharged after anti-inflammatory therapy for one week.
CONCLUSION
PG is a rarely reported disease, and 10% of newborns develop mild clinical symptoms consisting of urticaria-like or vesicular skin lesions. We intend to remind clinicians to consider this condition when a patient presents with such lesions so that treatment can be started early and neonatal morbidity can be taken into account.
Core Tip: Pemphigoid gestationis (PG) is a rarely reported disease, and 10% of newborns develop mild clinical symptoms consisting of urticaria-like or vesicular skin lesions. Our patient was diagnosed with PG at 8 mo of gestation and was performed by cesarean section at 37 + 4 wk of gestation. The infant had urticaria-like and vesicular skin lesions and was diagnosed with PG. We intend to remind clinicians to consider this condition when a patient presents with such lesions so that treatment can be started early and neonatal morbidity can be taken into account.
