Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 6, 2021; 9(34): 10540-10548
Published online Dec 6, 2021. doi: 10.12998/wjcc.v9.i34.10540
Combined lumbar muscle block and perioperative comprehensive patient-controlled intravenous analgesia with butorphanol in gynecological endoscopic surgery
Rong-Yu Zhu, Si-Qu Xiang, Dou-Ren Chen
Rong-Yu Zhu, Si-Qu Xiang, Department of Anesthesiology, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, Hubei Province, China
Dou-Ren Chen, Department of Pharmacy, Huai’an Hospital Affiliated to Xuzhou Medical University, Huai’an 223002, Jiangsu Province, China
Author contributions: Zhu RY and Xiang SQ designed the experiment; Zhu RY and Xiang SQ contributed equally and considered as co-first authors; Chen DR drafted the work; Zhu RY collected the data; Xiang SQ analyzed and interpreted data; Zhu RY and Chen DR wrote the article.
Institutional review board statement: This study was approved by the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture Ethics Committee.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dou-Ren Chen, BM BCh, Chief Pharmacist, Department of Pharmacy, Huai’an Hospital Affiliated to Xuzhou Medical University, No. 60 Huaihai South Road, Huai’an 223002, Jiangsu Province, China. chenqq1789ss@sina.com
Received: August 6, 2021
Peer-review started: August 6, 2021
First decision: September 1, 2021
Revised: September 8, 2021
Accepted: October 14, 2021
Article in press: October 14, 2021
Published online: December 6, 2021
Processing time: 116 Days and 1.7 Hours
Abstract
BACKGROUND

Laparoscopic surgery has become a common surgical approach for the clinical treatment of intra-abdominal lesions in recent years. We hypothesized that lumbar block with postoperative patient-controlled intravenous analgesia (PCIA) by butorphanol after gynecological surgery under general anesthesia would be more effective than PCIA by butorphanol alone.

AIM

To investigate the effect of lumbar block with PCIA by butorphanol after gynecological surgery under general anesthesia.

METHODS

This study assessed 120 women scheduled for laparoscopic surgery at our hospital between May 2017 and May 2020. They were divided using a random number table into a research group (those who received quadratus lumborum block combined with PCIA analgesia by butorphanol) and a control group (those who received only PCIA analgesia by butorphanol), with 60 patients in each group. Demographic factors, visual analog scale scores for pain, serum inflammatory markers, PCIA compressions, Ramsay scores, and adverse events were compared between groups using a t-test, analysis of variance, or χ2 test, as appropriate.

RESULTS

There were no significant differences in demographic factors between groups (all P > 0.05). The visual analog scale scores of the research group in the resting state 12 h and 24 h postoperatively were significantly lower than those of the control group (P < 0.05). Two hours after surgery, there were no significant differences in the levels of serum tumor necrosis factor-α, interleukin (IL)-6, or IL-8 between groups (P > 0.05). The serum tumor necrosis factor-α levels of the research group 24 h postoperatively were significantly lower than those of the control group (P < 0.05). The levels of serum IL-6 and IL-8 in the study group 24 h and 48 h postoperatively were significantly lower than those in the control group (P < 0.05).

CONCLUSION

Lumbar block with PCIA with butorphanol after gynecological surgery under general anesthesia significantly improves the analgesic effect and reduces the degree of inflammation, instances of PCIA compression, and adverse reactions.

Keywords: Quadratus lumborum block; Butorphanol; Patient-controlled intravenous analgesia; Analgesic effect

Core Tip: A total of 120 cases of patients undergoing laparoscopic surgery in our hospital were taken as the research subjects, and it was confirmed that gynecological surgery combined with patient-controlled intravenous analgesia combined with butorphanol can significantly improve the analgesic effect, reduce the degree of inflammation, reduce the times of patient-controlled intravenous analgesia compression, and adverse reactions in patients.