Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.9101
Peer-review started: December 11, 2020
First decision: January 17, 2021
Revised: January 31, 2021
Accepted: August 23, 2021
Article in press: August 23,2021
Published online: October 26, 2021
Processing time: 313 Days and 21.6 Hours
Granular cell tumor (GCT) of the pancreas is a rare neurogenic tumor. The first case of pancreatic GCT was described in 1975, and up to now, only 7 cases have been reported.
A 53-year-old male had a pancreatic mass for 1 mo. He was not treated at the local hospital, but referred to Henan Tumor Hospital for surgery. Preoperative imaging revealed a 2.0 cm × 2.5 cm-sized mass located in the body of the pancreas. At the microscopic level, a large number of eosinophilic particles are present in the oval tumor cells. The immunohistochemistry of this tumor cell display CD56 (+), blood vessels CD34 (+), Ki-67 (+) < 10%, and S-100 (+).
GCT of the pancreas should be recognized as a preoperative differential diagnosis of pancreatic tumors. Surgical resection of the tumor should be attempted; however, GCT of the pancreas has a certain rate of tumor metastasis and recurrence. Therefore, GCT of the pancreas requires regular and long-term follow-up.
Core Tip: Granular cell tumor (GCT) of the pancreas is a rare neurogenic tumor. We present a rare case of pancreatic GCT, which recovered successfully after surgical treatment. We reviewed 7 previous cases of the same tumor and conclude that most of the pancreatic GCTs are benign, but there is a potential malignancy. Surgery is an important treatment for this disease, and there is a certain rate of tumor metastasis and recurrence after surgery, so regular reexamination should be insisted on.