Zhu MH, Nie CF. Particular tumor of the pancreas: A case report . World J Clin Cases 2021; 9(30): 9101-9107 [PMID: 34786392 DOI: 10.12998/wjcc.v9.i30.9101]
Corresponding Author of This Article
Chang-Fu Nie, PhD, Chief Doctor, Department of Hepatopancreatobiliary Surgery, the Affiliated Cancer Hospital of Zhengzhou University, No. 127 Dongming Road, Zhengzhou 450008, Henan Province, China. zhuminghui258@163.com
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Surgery
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Case Report
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Oct 26, 2021 (publication date) through Nov 6, 2025
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World Journal of Clinical Cases
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Zhu MH, Nie CF. Particular tumor of the pancreas: A case report . World J Clin Cases 2021; 9(30): 9101-9107 [PMID: 34786392 DOI: 10.12998/wjcc.v9.i30.9101]
World J Clin Cases. Oct 26, 2021; 9(30): 9101-9107 Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.9101
Particular tumor of the pancreas: A case report
Ming-Hui Zhu, Chang-Fu Nie
Ming-Hui Zhu, Department of General Surgery, Zhengzhou People's Hospital, Zhengzhou 450008, Henan Province, China
Chang-Fu Nie, Department of Hepatopancreatobiliary Surgery, the Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, Henan Province, China
Author contributions: Zhu MH and Nie CF were the patient’s surgeons and had participated in the surgical treatment of the patient, review of articles, as well as collecting radiological and pathological data; Nie CF contributed to the revisioning and polishing of the paper; Both authors approved the final version.
Supported byHenan Science and Technology Research Project, No. 162102310045.
Informed consent statement: All studies in this article have passed ethical review, and relevant materials have been approved by the patient and authorized to use.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chang-Fu Nie, PhD, Chief Doctor, Department of Hepatopancreatobiliary Surgery, the Affiliated Cancer Hospital of Zhengzhou University, No. 127 Dongming Road, Zhengzhou 450008, Henan Province, China. zhuminghui258@163.com
Received: December 11, 2020 Peer-review started: December 11, 2020 First decision: January 17, 2021 Revised: January 31, 2021 Accepted: August 23, 2021 Article in press: August 23,2021 Published online: October 26, 2021 Processing time: 313 Days and 21.6 Hours
Abstract
BACKGROUND
Granular cell tumor (GCT) of the pancreas is a rare neurogenic tumor. The first case of pancreatic GCT was described in 1975, and up to now, only 7 cases have been reported.
CASE SUMMARY
A 53-year-old male had a pancreatic mass for 1 mo. He was not treated at the local hospital, but referred to Henan Tumor Hospital for surgery. Preoperative imaging revealed a 2.0 cm × 2.5 cm-sized mass located in the body of the pancreas. At the microscopic level, a large number of eosinophilic particles are present in the oval tumor cells. The immunohistochemistry of this tumor cell display CD56 (+), blood vessels CD34 (+), Ki-67 (+) < 10%, and S-100 (+).
CONCLUSION
GCT of the pancreas should be recognized as a preoperative differential diagnosis of pancreatic tumors. Surgical resection of the tumor should be attempted; however, GCT of the pancreas has a certain rate of tumor metastasis and recurrence. Therefore, GCT of the pancreas requires regular and long-term follow-up.
Core Tip: Granular cell tumor (GCT) of the pancreas is a rare neurogenic tumor. We present a rare case of pancreatic GCT, which recovered successfully after surgical treatment. We reviewed 7 previous cases of the same tumor and conclude that most of the pancreatic GCTs are benign, but there is a potential malignancy. Surgery is an important treatment for this disease, and there is a certain rate of tumor metastasis and recurrence after surgery, so regular reexamination should be insisted on.
