Clinical application of repetitive transcranial magnetic stimulation for post-traumatic stress disorder: A literature review

doi:10.12998/wjcc.v9.i29.8658

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World Journal of Clinical Cases

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World J Clin Cases. Oct 16, 2021; 9(29): 8658-8665
Published online Oct 16, 2021. doi: 10.12998/wjcc.v9.i29.8658

Clinical application of repetitive transcranial magnetic stimulation for post-traumatic stress disorder: A literature review

Peng Cheng, Ying Zhou, Li-Zhi Xu, Ya-Fei Chen, Ruo-Lin Hu, Yi-Ling Zou, Ze-Xuan Li, Li Zhang, Qi Shun, Xun Yu, Ling-Jiang Li, Wei-Hui Li

Peng Cheng, Ying Zhou, Li-Zhi Xu, Ze-Xuan Li, Li Zhang, Ling-Jiang Li, Wei-Hui Li, National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China

Ya-Fei Chen, Xiangya Medical School, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China

Ruo-Lin Hu, Yi-Ling Zou, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China

Qi Shun, Research Center for Brain Science and Human-like Intelligence, Xi’an Jiaotong University, Xi’an 710049, Shannxi Province, China

Xun Yu, Product Department, Solide Brain Medical Technology, Ltd., Xi’an 710043, Shannxi Province, China

Author contributions: Cheng P collected the data; Cheng P, Zhou Y, Xu LZ, and Chen YF reviewed and translated the literature; Cheng P, Li ZX, Zhang L, Li LJ, and Li WH drafted the manuscript; Zhou Y, Xu LZ, and Chen YF translated the literature; Hu RL, Zou YL, and Zhang L managed the process of the literature review; Shun Q and Yu X prepared the figures and updated the literature; and Li LJ and Li WH drafted the manuscript.

Supported by Science and Technology Innovation Plan of Hunan, China, No. 2018JJ2592; and Hunan Key Research and Development Program, No. 2018SK2136.

Conflict-of-interest statement: The authors declare that they do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.

Corresponding author: Wei-Hui Li, MD, PhD, Chief Doctor, Full Professor, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, No. 932 Lushan South Road, Changsha 410011, Hunan Province, China. weihui_li@csu.edu.cn

Received: February 25, 2021
Peer-review started: February 25, 2021
First decision: April 21, 2021
Revised: April 30, 2021
Accepted: August 20, 2021
Article in press: August 20, 2021
Published online: October 16, 2021
Processing time: 232 Days and 1 Hours

Abstract

The efficacy of traditional treatment for post-traumatic stress disorder (PTSD) is still unsatisfactory. Repetitive transcranial magnetic stimulation (rTMS) has been widely used in the treatment of various types of mental disorders, including PTSD. Although rTMS has been demonstrated to be effective in many cases, there are still arguments regarding its mechanism and protocol. This review aims to summarize the origin, development, principle, and future direction of rTMS and introduce this neuro-stimulation therapy to relevant clinicians.

Keywords: Repetitive transcranial magnetic stimulation; Post-traumatic stress disorder; Neuro-stimulation; Physical therapy

Core Tip: This review concludes the update clinical development of repetitive transcranial magnetic stimulation (rTMS) in the treatment of post-traumatic stress disorder, providing the detail explanation of this emerging physical therapy. This review aims to summarize the origin, development, principle, and future direction of rTMS and introduce this neuro-stimulation therapy to relevant clinicians.