Zhou J, Yang Z, Yang CS, Lin H. Paraneoplastic focal segmental glomerulosclerosis associated with gastrointestinal stromal tumor with cutaneous metastasis: A case report. World J Clin Cases 2021; 9(27): 8120-8126 [PMID: 34621870 DOI: 10.12998/wjcc.v9.i27.8120]
Corresponding Author of This Article
Hua Lin, BM BCh, Nurse, Department of Nursing, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, No. 43 Renmin Road, Haidian Island, Haikou 570208, Hainan Province, China. 2894993270@qq.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Sep 26, 2021; 9(27): 8120-8126 Published online Sep 26, 2021. doi: 10.12998/wjcc.v9.i27.8120
Paraneoplastic focal segmental glomerulosclerosis associated with gastrointestinal stromal tumor with cutaneous metastasis: A case report
Jun Zhou, Zhen Yang, Cui-Shun Yang, Hua Lin
Jun Zhou, Zhen Yang, Cui-Shun Yang, Department of Nephrology and Rheumatology, Haikou People’s Hospital Affiliated to Xiangya School of Medicine of Central South University, Haikou 570208, Hainan Province, China
Hua Lin, Department of Nursing, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou 570208, Hainan Province, China
Author contributions: Zhou J wrote the manuscript, conducted the literature review, and participated in paper submission and revision; Yang Z, Yang CS, and Lin H participated in the clinical care of the patient; all authors assisted with the interpretation of the results and manuscript revision, and read and approved the final manuscript.
Supported bythe Hainan Provincial Natural Science Foundation of China, No. 820RC785; and the Healthy Department of Hainan Province, No. 2001320243A2011.
Informed consent statement: Written informed consent was obtained from the patient. A copy of the consent form is available for review and can be provided on request.
Conflict-of-interest statement: The authors declare that they have no competing interests to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hua Lin, BM BCh, Nurse, Department of Nursing, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, No. 43 Renmin Road, Haidian Island, Haikou 570208, Hainan Province, China. 2894993270@qq.com
Received: April 3, 2021 Peer-review started: April 3, 2021 First decision: July 15, 2021 Revised: July 25, 2021 Accepted: August 5, 2021 Article in press: August 5, 2021 Published online: September 26, 2021 Processing time: 165 Days and 18 Hours
Abstract
BACKGROUND
Gastrointestinal stromal tumor (GIST) with cutaneous metastasis is very rare. As a result, cutaneous GISTs have not been well characterized. Focal segmental glomerulosclerosis (FSGS) is also a rare symptom among paraneoplastic nephritic syndromes (PNS).
CASE SUMMARY
In this case report, we describe a patient with cutaneous metastatic GIST accompanied by nephrotic syndrome occurring as a malignancy-associated PNS, for whom symptomatic treatment was ineffective, but clinical remission was achieved after surgery. Moreover, the patient has a missense mutation in NPHP4, which can explain the occurrences of GIST and FSGS in this patient and indicates that the association is not random.
CONCLUSION
This is the first reported case of a GIST with cutaneous metastasis accompanied by nephrotic syndrome manifesting as a PNS.
Core Tip: This paper reports the case of patient with cutaneous metastatic gastrointestinal stromal tumor accompanied by nephrotic syndrome occurring as a malignancy-associated paraneoplastic nephritic syndromes. Moreover, the patient has a missense mutation in NPHP4. A review of other relevant cases from the literature is presented, and the potential challenges, treatment, and prognosis are discussed.
