Published online Sep 16, 2021. doi: 10.12998/wjcc.v9.i26.7930
Peer-review started: April 19, 2021
First decision: May 24, 2021
Revised: June 1, 2021
Accepted: July 22, 2021
Article in press: July 22, 2021
Published online: September 16, 2021
Processing time: 143 Days and 17.7 Hours
Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas among adults. It is characterized by large size, high grade, and biological aggressiveness. There are many reports of MFH after local stimulation, such as bone fracture, implants, and chronic osteomyelitis. In this paper, we report a patient who developed MFH 6 years after amputation, suggesting that wound healing and mechanical force play a role in the local stimulation of this disease.
A 66-year-old man complained of persistent pain in his residual mid-thigh. He had undergone amputation surgery due to a traffic accident 6 years prior. Physical examination showed tenderness but no abnormalities in appearance. X-ray radiographs and magnetic resonance imaging supported the diagnosis of a tumor, and a biopsy confirmed that the lesion was MFH. The patient received neoadjuvant chemotherapy and left hip disarticulation. During the 6-mo follow-up, there were no symptoms of recurrence.
Postsurgery MFH has been reported before, and many studies have attributed it to the biological effects of implants. Our case report shows that this disease can develop without an implant and thus highlights the importance of local stimulation. The wound-healing process and mechanical force can both promote this tumor, but whether they directly cause MFH needs further investigation.
Core Tip: In this paper, we report a patient who developed malignant fibrous histiocytoma 6 years after amputation, suggesting the role of wound-healing and mechanical force as local stimulation in this disease.