Nedaplatin-induced syndrome of inappropriate secretion of antidiuretic hormone: A case report and review of the literature

doi:10.12998/wjcc.v9.i23.6810

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Aug 16, 2021 (publication date) through Mar 1, 2026

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World Journal of Clinical Cases

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World J Clin Cases. Aug 16, 2021; 9(23): 6810-6815
Published online Aug 16, 2021. doi: 10.12998/wjcc.v9.i23.6810

Nedaplatin-induced syndrome of inappropriate secretion of antidiuretic hormone: A case report and review of the literature

Lei Tian, Li-Ya He, Hong-Zhen Zhang

Lei Tian, Li-Ya He, Hong-Zhen Zhang, Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China

Author contributions: Tian L reviewed the literature and wrote the manuscript; He LY was the patient’s doctor in charge; Zhang HZ contributed to the literature review; and all authors have read and approved the final manuscript.

Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: Hong-Zhen Zhang, PhD, Doctor, Department of Oncology, Hebei General Hospital, No. 348 Heping West Road, Shijiazhuang 050051, China. 1256596529@qq.com

Received: February 1, 2021
Peer-review started: February 1, 2021
First decision: April 25, 2021
Revised: May 6, 2021
Accepted: May 19, 2021
Article in press: May 19, 2021
Published online: August 16, 2021
Processing time: 185 Days and 4.9 Hours

Abstract

BACKGROUND

Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is relatively common in several cancers, such as small cell lung cancer. However, nedaplatin-induced SIADH is rare. We describe a case of SIADH mediated by nedaplatin.

CASE SUMMARY

A 54-year-old female with nasopharyngeal carcinoma was treated with nedaplatin and developed severe hyponatremia due to SIADH. The side effects were successfully treated by fluid restriction and sodium supplementation.

CONCLUSION

This case report highlights the importance of cautiously treating life-threatening hyponatremia in patients treated with nedaplatin.

Keywords: Nedaplatin; Syndrome of inappropriate secretion of antidiuretic hormone; Hyponatremia; Fluid restriction; Sodium supplementation; Case report

Core Tip: Nedaplatin has been shown to be an effective drug in a variety of cancers. Due to its wide application, it is important to pay attention to its side effects, especially rare side effects. Here, we report a case of a severe, rare syndrome of inappropriate secretion of antidiuretic hormone after initiating nedaplatin chemotherapy. Timely diagnosis, fluid restriction and sodium supplementation may be the most appropriate treatments.