Zhao CJ, Ma GZ, Wang YJ, Wang JH. Splenic Kaposi’s sarcoma in a human immunodeficiency virus-negative patient: A case report. World J Clin Cases 2021; 9(18): 4765-4771 [PMID: 34222445 DOI: 10.12998/wjcc.v9.i18.4765]
Corresponding Author of This Article
Jin-Hong Wang, BMed, MS, Research Scientist, College of Life Science, Shaanxi Normal University, No. 620 West Chang'an Avenue, Chang'an District, Xi'an 710119, Shaanxi Province, China. jinhong@snnu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 26, 2021; 9(18): 4765-4771 Published online Jun 26, 2021. doi: 10.12998/wjcc.v9.i18.4765
Splenic Kaposi’s sarcoma in a human immunodeficiency virus-negative patient: A case report
Chuan-Jie Zhao, Guang-Zhen Ma, Yan-Jun Wang, Jin-Hong Wang
Chuan-Jie Zhao, Department of Hepatobiliary Surgery, Liaocheng Second People’s Hospital, Linqing 252600, Shandong Province, China
Guang-Zhen Ma, Department of Pathology, Liaocheng Second People’s Hospital, Linqing 252600, Shandong Province, China
Yan-Jun Wang, Department of Medical Oncology, Liaocheng Second People’s Hospital, Linqing 252600, Shandong Province, China
Jin-Hong Wang, College of Life Science, Shaanxi Normal University, Xi'an 710119, Shaanxi Province, China
Author contributions: Zhao CJ and Wang JH contributed to the study conception; Wang JH contributed to the design and supervision; Zhao CJ, Ma GZ and Wang YJ contributed resources; Zhao CJ and Ma GZ contributed materials; Zhao CJ, Ma GZ and Wang YJ contributed to the data collection and/or processing; Zhao CJ and Wang JH contributed to the analysis and/or interpretation; Wang JH contributed to the literature search; Wang JH wrote manuscript and critically revised it for important intellectual content.
Informed consent statement: Informed written consent was obtained from the patient and legal guardian for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Hong Wang, BMed, MS, Research Scientist, College of Life Science, Shaanxi Normal University, No. 620 West Chang'an Avenue, Chang'an District, Xi'an 710119, Shaanxi Province, China. jinhong@snnu.edu.cn
Received: December 22, 2020 Peer-review started: December 22, 2020 First decision: March 11, 2021 Revised: March 22, 2021 Accepted: April 23, 2021 Article in press: April 23, 2021 Published online: June 26, 2021 Processing time: 171 Days and 0.8 Hours
Abstract
BACKGROUND
Kaposi’s sarcoma (KS) is a malignancy that usually affects the skin of the lower extremities, and may involve internal organs. It originates from the vascular endothelium. It is well known that the development of KS is associated with human herpes virus 8 (i.e. HHV8) infections. Sporadic KS cases have mainly been found in Africa. Isolated splenic KS in Asia has rarely been reported. We present here a case of KS primarily involving the spleen in a human immunodeficiency virus (HIV)-negative Chinese patient.
CASE SUMMARY
A 50-year-old male patient was admitted to hospital due to abdominal distension and discomfort, reduced food intake and weight loss. Medical examination revealed that the patient had moderate anemia, a low platelet count, slight fatty liver and a huge mass in the spleen. Spleen lymphoma was considered. An anti-HIV test was negative. The whole spleen was surgically excised. The final pathological diagnosis was nodular stage spleen KS, and the patient underwent total splenectomy. He recovered well and was discharged from hospital 12 d after surgery. Two weeks later, the patient developed liver metastasis and died within 1 mo after surgery.
CONCLUSION
KS is difficult to diagnose and pathological examination is necessary. KS has a poor prognosis and should be diagnosed and treated early to improve survival.
Core Tip: This case describes a rare Splenic Kaposi’s sarcoma (KS) in a human immunodeficiency virus-negative patient. The preoperative diagnosis was lymphoma, but the postoperative pathological diagnosis was KS. The operation and lack of proper postoperative treatments for KS may promote liver metastasis and death, as in this case. Improving the overall understanding of KS is paramount. Therefore, we report this case to provide KS experiences and lessons for future clinical works.
