Published online May 26, 2021. doi: 10.12998/wjcc.v9.i15.3675
Peer-review started: November 30, 2020
First decision: February 28, 2021
Revised: March 3, 2021
Accepted: March 23, 2021
Article in press: March 23, 2021
Published online: May 26, 2021
Processing time: 162 Days and 0.3 Hours
Infiltrating ductal breast carcinoma with monoclonal gammopathy of undetermined significance (MGUS) is rare and easily misdiagnosed. Most patients are first diagnosed with MGUS. We report a rare case of MGUS secondary to infiltrating ductal breast carcinoma. We also review the literature to analyze the clinical characteristics and diagnostic methods.
A 51-year-old woman underwent modified radical mastectomy for infiltrating ductal carcinoma of the right breast and was then treated with radiation and chemotherapy. A decreased platelet count was found on routine blood examination, and MGUS was subsequently diagnosed. This is the first report of the occurrence of MGUS after breast cancer surgery.
Vigilance is required to distinguish this rare comorbidity from breast plasmacytoma.
Core Tip: With age, the risk of monoclonal gammopathy of undetermined significance increases, ranging from 2% to 3% over the age of 50 and approximately 5% over the age of 70. In addition, obesity increases the risk relatively. The cause is unclear. Genetic factors, environmental factors, radiation and chemicals (such as pesticides, herbicides) may have a certain impact on the occurrence of this disease. The risk of infection is higher than normal, the risk of osteoporosis and fractures is increased, and the risk of thrombosis is increased. Tumors with monoclonal gammopathy of undetermined significance should be given more attention.