Yang L, Liang H, Liu L, Guo L, Ying JM, Shi SS, Hu XS. CD56+ lymphoepithelioma-like carcinoma of the lung: A case report and literature review. World J Clin Cases 2020; 8(7): 1257-1264 [PMID: 32337200 DOI: 10.12998/wjcc.v8.i7.1257]
Corresponding Author of This Article
Xing-Sheng Hu, MD, Doctor, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuannanli, Chaoyang District, Beijing 100021, China. huxingsheng66@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Apr 6, 2020; 8(7): 1257-1264 Published online Apr 6, 2020. doi: 10.12998/wjcc.v8.i7.1257
CD56+ lymphoepithelioma-like carcinoma of the lung: A case report and literature review
Lin Yang, Hua Liang, Li Liu, Lei Guo, Jian-Ming Ying, Su-Sheng Shi, Xing-Sheng Hu
Lin Yang, Li Liu, Lei Guo, Jian-Ming Ying, Su-Sheng Shi, Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Hua Liang, Department of Medical Oncology, Qingdao Central Hospital, Qingdao 266042, Shandong Province, China
Xing-Sheng Hu, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Yang L and Liang H contributed equally to this research. Hu X and Shi S contributed to the conception of the study; Yang L and Liang H collected the clinical data; Liu L and Guo L reviewed the literature; Yang L, Liang H, Liu L, and Ying JM participated in the preparation of the manuscript; Hu XS and Shi SS contributed to the revision of the manuscript; all authors approved the version to be submitted.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xing-Sheng Hu, MD, Doctor, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuannanli, Chaoyang District, Beijing 100021, China. huxingsheng66@163.com
Received: December 25, 2019 Peer-review started: December 25, 2019 First decision: February 20, 2020 Revised: February 24, 2020 Accepted: March 22, 2020 Article in press: March 22, 2020 Published online: April 6, 2020 Processing time: 103 Days and 1.1 Hours
Abstract
BACKGROUND
Lymphoepithelioma-like carcinoma (LELC) is a non-keratinizing carcinoma with rich lymphocytic infiltration, which primarily originates from the nasopharynx. Primary lung LELC is a type of lung cancer with a relatively low incidence. Herein, we report a rare case of lung LELC with expression of CD56. We also performed a literature review to summarize the epidemiological, clinical, and prognostic features of this disease.
CASE SUMMARY
A 51-year-old man was admitted to Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College due to cough and chest pain lasting > 2 mo and 1 wk, respectively. Positron emission tomography-computed tomography and magnetic resonance imaging examinations revealed the presence of a mass in the right upper lobe with enlargement of lymph nodes and multiple bone metastases. According to the results of bronchoscopy and cervical lymph node biopsy, a diagnosis of lung LELC with CD56-positive staining (CD56+ lung LELC) was made. In the literature, 458 cases of lung LELC have been reported. However, only one other case of CD56+ lung LELC has been reported thus far.
CONCLUSION
The mechanism and potential role of CD56 expression in CD56+ lung LELC require further investigation.
Core tip: Primary lung lymphoepithelioma-like carcinoma (LELC) is a rare type of lung carcinoma without established international diagnostic criteria. For this reason, misdiagnosis may occasionally occur and differential diagnosis with other lung primary carcinomas is required. Herein, we report a 51-year old man with CD56-positive lung LELC, which should be differentiated from large cell neuroendocrine carcinoma. A total of 458 cases of lung LELC have been reported in the literature. This case is the second documented case of CD56-positive lung LELC. The mechanism and potential role of CD56 expression in lung LELC require further investigation.
Share the Article
Yang L, Liang H, Liu L, Guo L, Ying JM, Shi SS, Hu XS. CD56+ lymphoepithelioma-like carcinoma of the lung: A case report and literature review. World J Clin Cases 2020; 8(7): 1257-1264 [PMID: 32337200 DOI: 10.12998/wjcc.v8.i7.1257]
