Synchronous colonic mucosa-associated lymphoid tissue lymphoma found after surgery for adenocarcinoma: A case report and review of literature

doi:10.12998/wjcc.v8.i24.6456

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 8, Issue 24

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7128)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-5) series.

Item

Count

PDF

465

WORD

202

HTML

2722

Figures (1-5)

547

Sum=3936

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

948

Download

2247

Sum=3195

Dec 26, 2020 (publication date) through Feb 20, 2026

Times Cited of This Article

Times Cited (3)

Journal Information of This Article

Publication Name

World Journal of Clinical Cases

ISSN

2307-8960

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Case Report

World J Clin Cases. Dec 26, 2020; 8(24): 6456-6464
Published online Dec 26, 2020. doi: 10.12998/wjcc.v8.i24.6456

Synchronous colonic mucosa-associated lymphoid tissue lymphoma found after surgery for adenocarcinoma: A case report and review of literature

Juan-Juan Li, Bing-Chen Chen, Jie Dong, Yuan Chen, You-Wei Chen

Juan-Juan Li, Department of Intensive Care Unit and Comprehensive Support, Wang-Jiang-Shan Branch of Zhejiang Provincial People's Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China

Bing-Chen Chen, Department of Colorectal Surgery, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China

Jie Dong, You-Wei Chen, Department of Gastroenterology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China

Yuan Chen, Department of Pathology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China

Author contributions: Li JJ was responsible for collecting the medical history of the patient and drafting the paper; Chen BC was the patient’s doctor and performed colonoscopy and endoscopic mucosal resection; Dong J was responsible for drafting the paper; Chen Y was the pathologist who provided the pathological results; Chen YW reviewed the literature and revised the manuscript; all authors issued the final approval for the version to be submitted.

Informed consent statement: Informed written consent was obtained from the patient to publish this report and any accompanying images.

Conflict-of-interest statement: The authors have declared that no conflicts of interest exist.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: You-Wei Chen, MSc, Chief Doctor, Department of Gastroenterology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou 310014, Zhejiang Province, China. cyw@zju.edu.cn

Received: September 4, 2020
Peer-review started: September 4, 2020
First decision: September 30, 2020
Revised: October 11, 2020
Accepted: October 26, 2020
Article in press: October 26, 2020
Published online: December 26, 2020
Processing time: 106 Days and 2.3 Hours

Abstract

BACKGROUND

Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of non-Hodgkin lymphoma that is mainly involved in the gastrointestinal tract. The synchronous occurrence of colonic MALT lymphoma and adenocarcinoma in the same patient is extremely rare. We here report a case of synchronous colonic MALT lymphoma found on surveillance colonoscopy five months after surgery and chemotherapy for sigmoid adenocarcinoma.

CASE SUMMARY

A 67-year-old man was admitted because of hematochezia for two months. Colonoscopy suggested a colonic tumor before hospitalization. Abdominal computed tomography (CT) revealed local thickening of the sigmoid colon. The patient underwent a left hemicolectomy with local lymph node dissection. The histopathology revealed moderately differentiated adenocarcinoma and partially mucinous adenocarcinoma. The pTNM stage was T3N1Mx. The patient received chemotherapy with six cycles of mFOLFOX6 after surgery. Colonoscopy was performed five months later and revealed single, flat, polypoid lesions of the colon 33 cm away from the anus. Subsequently, the patient underwent endoscopic mucosal resection for further diagnosis. The pathological diagnosis was MALT lymphoma. Positron emission tomography /CT suggested metastasis. The patient refused further treatment and died ten months later.

CONCLUSION

Colonic MALT lymphoma may occur after surgery and chemotherapy for adenocarcinoma as a synchronous malignancy. Regular surveillance colonoscopy and careful monitoring after surgery are critical.

Keywords: Mucosa-associated lymphoid tissue lymphoma; Adenocarcinoma; Colon; Synchronous malignancy; Surgery; Case report

Core Tip: The synchronous occurrence of colonic mucosa-associated lymphoid tissue (MALT) lymphoma and adenocarcinoma in the same patient is extremely rare. Few cases have been reported in the literature to date. Colonic MALT lymphoma is often asymptomatic and found on surveillance colonoscopy. When it presents synchronously with colonic adenocarcinoma, MALT lymphoma is easily missed. Regular surveillance colonoscopy and careful monitoring after surgery are critical. We report a case of synchronous colonic MALT lymphoma found on surveillance colonoscopy five months after surgery and chemotherapy for sigmoid adenocarcinoma.