Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2019; 7(20): 3289-3295
Published online Oct 26, 2019. doi: 10.12998/wjcc.v7.i20.3289
Termination of a partial hydatidiform mole and coexisting fetus: A case report
Rui-Qing Zhang, Jia-Rong Zhang, Shuang-Di Li
Rui-Qing Zhang, Jia-Rong Zhang, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200120, China
Shuang-Di Li, Shanghai First Maternity and Infant Hospital, Shanghai 200120, China
Author contributions: Li SD and Zhang JR contributed equally to this work; Li SD and Zhang JR put forward the idea; Zhang RQ collected and analyzed the data; Li SD and Zhang RQ wrote the paper.
Informed consent statement: All study participants provided written informed consent prior to study enrollment.
Conflict-of-interest statement: All authors declare no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shuang-Di Li, MD, PhD, Doctor, Shanghai First Maternity and Infant Hospital, Pudong New Area, Shanghai 200120, China. lishuangdi21@126.com
Telephone: +86-21-37798537 Fax: +86-21-37798537
Received: April 6, 2019
Peer-review started: April 8, 2019
First decision: August 1, 2019
Revised: August 22, 2019
Accepted: September 9, 2019
Article in press: September 9, 2019
Published online: October 26, 2019
Processing time: 204 Days and 13.3 Hours
Abstract
BACKGROUND

We describe the treatment strategy for a patient who was found to have a partial hydatidiform mole and coexisting fetus (PHMCF) during the second trimester. The patient was a 38-year-old Chinese woman who had become pregnant following in vitro fertilization and embryo transplantation. We wanted to determine the safest therapeutic strategy to terminate the PHMCF during the second trimester.

CASE SUMMARY

In this case, we present a patient who was found to have a PHMCF complicated with serious continuous vaginal bleeding and pre-eclampsia during the second trimester. After careful evaluation, the pregnancy was considered to be unsustainable and was terminated via caesarean section (CS). An infant with weak vital signs and a partially cystic placenta measuring 110 mm × 95 mm × 35 mm were delivered by CS. The patient was discharged after 4 d. The serum levels of β-human chorionic gonadotropin decreased to within a normal range 5 wk after the operation, and no evidence of persistent trophoblastic disease or lung metastases was noticed at the 6-mo follow-up.

CONCLUSION

CS termination of PHMCF during the second trimester may be a relatively safe therapeutic strategy.

Keywords: Partial hydatidiform mole and coexisting fetus; Caesarean section; Second trimester; Case report

Core tip: A partial hydatidiform mole and coexisting fetus (PHMCF), a rare phenomenon in the past, is showing an upward trend in frequency due to the increasing use of assisted reproductive technologies. Our main objective was to find the safest therapeutic strategy to terminate a PHMCF during the second trimester. We determined that termination of PHMCF during the second trimester via caesarean section is a relatively safe therapeutic strategy.