Published online Jun 6, 2019. doi: 10.12998/wjcc.v7.i11.1344
Peer-review started: December 29, 2018
First decision: March 10, 2019
Revised: April 9, 2019
Accepted: May 1, 2019
Article in press: May 2, 2019
Published online: June 6, 2019
Processing time: 161 Days and 5.8 Hours
Pancreatic liposarcoma is a rare tumor. According to a literature review, the patient described in this study is the seventh case of pancreatic liposarcoma reported in the English literature and the third case of dedifferentiated liposarcoma. Furthermore, this case had the largest primary tumor volume, and a primary pancreatic liposarcoma was diagnosed based on sufficient evidence.
We here report a rare case of a 28-year-old female with a huge dedifferentiated liposarcoma in the pancreatic tail. In June 2015, the patient underwent distal pancreatectomy with splenectomy. During the operation, a huge liposarcoma of approximately 28.0 cm × 19.0 cm × 8.0 cm was found, which had a yellow and white fish-like incisal surface. Based on both pathology and MDM2 gene amplification, the tumor was diagnosed as a dedifferentiated liposarcoma. The patient was treated with surgery but declined postoperative chemotherapy. She was well at the 26-mo follow-up, and no relapse was observed.
Pancreatic liposarcoma has a low incidence. Chemotherapy should be included in the treatment regimens. Complete resection is the only effective treatment.
Core tip: Pancreatic liposarcoma is a rare tumor. We report a case of a 28-year-old female with a huge dedifferentiated liposarcoma in the pancreatic tail, 28.0 cm × 19.0 cm × 8.0 cm in size, with a yellow and white fish-like incisal surface. According to a literature review, this is the seventh case of pancreatic liposarcoma reported in the English literature and the third case of dedifferentiated liposarcoma. Furthermore, this case had the largest primary tumor volume, and a primary pancreatic liposarcoma was diagnosed based on sufficient evidence. The patient was treated with surgery but declined postoperative chemotherapy. She was well at the 26-mo follow-up, without relapse.