Published online Nov 6, 2018. doi: 10.12998/wjcc.v6.i13.703
Peer-review started: July 30, 2018
First decision: August 31, 2018
Revised: September 20, 2018
Accepted: October 11, 2018
Article in press: October 12, 2018
Published online: November 6, 2018
Processing time: 99 Days and 20.7 Hours
Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition of an unknown etiology and is often associated with immune diseases. However, PG rarely shows visceral involvement, especially in the kidney. A 20-year-old female presented with pedal edema and skin ulceration of both lower limbs. The skin lesion began as an erythematous plaque and then became a blister. She also complained of abdominal distension and a decreasing urine volume. Laboratory data showed high proteinuria, hypoalbuminemia and hyperlipidemia. Her skin and kidney were biopsied. The pathological results indicated PG and immunoglobulin A (IgA) nephropathy. The patient was finally cured with prednisolone in combination with cyclosporine A (CsA).
Core tip: This is the first report of successfully treated pyoderma gangrenosum (PG) occurring concurrently with immunoglobulin A (IgA) nephropathy. Both are immune-mediated disorders and should be paid attention to.