Effect of Helicobacter pylori eradication on elder cases: Observational study in community-based medicine

doi:10.12998/wjcc.v5.i12.412

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World Journal of Clinical Cases

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Observational Study

World J Clin Cases. Dec 16, 2017; 5(12): 412-418
Published online Dec 16, 2017. doi: 10.12998/wjcc.v5.i12.412

Effect of Helicobacter pylori eradication on elder cases: Observational study in community-based medicine

Masaki Maruyama, Kenya Kamimura, Ayako Hoshiyama, Koki Hoshiyama, Mari Hoshiyama, Yoshihiro Hoshiyama, Shuji Terai

Masaki Maruyama, Department of Gastroenterology, Kashiwazaki General Hospital and Medical Center, Kashiwazaki, Niigata 945-8535, Japan

Masaki Maruyama, Ayako Hoshiyama, Koki Hoshiyama, Mari Hoshiyama, Department of Internal Medicine, Kashiwazaki Chuo Hospital, Kashiwazaki, Niigata 945-0055, Japan

Kenya Kamimura, Shuji Terai, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Chuo-Ku, Niigata 951-8510, Japan

Yoshihiro Hoshiyama, Department of Surgery, Kashiwazaki Chuo Hospital, Kashiwazaki, Niigata 945-0055, Japan

Author contributions: All authors contributed to this manuscript.

Institutional review board statement: This study was reviewed and approved by the institutional review board of Kashiwazaki Central Hospital.

Informed consent statement: Written informed consents were obtained from the patients to present their information.

Conflict-of-interest statement: The authors declare that they have no current financial arrangement or affiliation with any organization that may have a direct influence on their work.

Correspondence to: Kenya Kamimura, MD, PhD, Assistant Professor, Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachido-ri, Chuo-ku, Niigata 951-8510, Japan. kenya-k@med.niigata-u.ac.jp

Telephone: +81-25-2272207 Fax: +81-25-2270776

Received: August 4, 2017
Peer-review started: August 8, 2017
First decision: September 20, 2017
Revised: September 27, 2017
Accepted: October 29, 2017
Article in press: October 29, 2017
Published online: December 16, 2017
Processing time: 124 Days and 19.7 Hours

Abstract

AIM

To examine the effect of Helicobacter pylori (H. pylori) eradication therapy on the extra-gastrointestinal factors in elderly patients by a before-after observational study in community medicine.

METHODS

Medical records (1 May 2013-31 January 2014) of 130 patients who underwent H. pylori eradication therapy with 2-year after-eradication observation in our institute were reviewed. Data on sex; age; body weight; body mass index (BMI); mean corpuscular volume (MCV); total protein; low-density lipoprotein cholesterol, triglyceride, haemoglobin A1c and haemoglobin levels and gastric hyperplastic polyps (GHPs) at eradication was extracted. Two-year after-eradication change in data was analysed by paired-sample t-test; relationship between GHPs and subclinical iron deficiency anaemia (IDA) improvement was evaluated.

RESULTS

The mean patient age (median, interquartile range) at eradication was 69.6 (71.5, 64-77) years. Paired-sample t-tests showed that body weight, BMI and MCV increased by 0.52 kg (P = 0.018), 0.25 kg/m² (P = 0.006) and 0.83 fL (P < 0.001), respectively. The nonparametric Mann-Whitney test showed no significant difference in the change rate of MCV after eradication between the groups with and without GHPs (P = 0.892).

CONCLUSION

H. pylori eradication therapy prevented weight loss and subclinical IDA in elderly individuals. GHPs were not associated with subclinical IDA.

Keywords: Helicobacter pylori; Iron deficiency anaemia; Body weight; Elderly; Polyp

Core tip: The effect of Helicobacter pylori (H. pylori) eradication therapy on the extra-gastrointestinal factors in elderly patients was focused in this study. H. pylori eradication therapy prevented weight loss and subclinical iron deficiency anaemia (IDA) in elderly individuals. Gastric hyperplastic polyps were not associated with subclinical IDA. The results obtained in this study will help physician to treat elderly patients in community-based medicine.