Observational Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2015; 3(2): 171-179
Published online Feb 16, 2015. doi: 10.12998/wjcc.v3.i2.171
Correlation between hypertension and hyperglycemia among young adults in India
Tanu Midha, Vinay Krishna, Rishi Shukla, Praveen Katiyar, Samarjeet Kaur, Dinesh Singh Martolia, Umeshwar Pandey, Yashwant Kumar Rao
Tanu Midha, Dinesh Singh Martolia, Department of Community Medicine, Government Medical College, Kannauj, Uttar Pradesh 209732, India
Vinay Krishna, Department of Cardiovascular and Thoracic Surgery, LPS Institute of Cardiology, Kanpur, Uttar Pradesh 208002, India
Rishi Shukla, Department of Endocrinology, Regency Hospital Pvt. Ltd. Kanpur, Uttar Pradesh 208002, India
Praveen Katiyar, University Institute of Health Sciences, Chatrapati Shahuji Maharaj University, Kanpur, Uttar Pradesh 208024, India
Samarjeet Kaur, Department of Community Medicine, GSVM Medical College, Kanpur, Uttar Pradesh 208002, India
Umeshwar Pandey, Department of Cardiology, LPS Institute of Cardiology, Kanpur, Uttar Pradesh 208002, India
Yashwant Kumar Rao, Department of Pediatrics, GSVM Medical College, Kanpur, Uttar Pradesh 208002, India
Author contributions: Midha T, Krishna V and Shukla R contributed to conception and design, acquisition of data, or analysis and interpretation of data, drafting the article and final approval of the version to be published; Katiyar P, Kaur S, Martolia DS, Pandey U and Rao YK helped in conception and design, and interpretation of data, revising the article and final approval of the version to be published.
Ethics approval: The manuscriot has been approved by the Institutional Ethical Committee of govt. Medical College, Kannauj, Uttar pradesh.
Informed consent: All study participants, provided informed written consent prior to study enrollment.
Conflict-of-interest: There are no conflicting interests (including but not limited to commercial, personal, political, intellectual, or religious interests) to declare.
Data sharing: Technical appendix, statistical code, and dataset available from the corresponding author at tanumidha2001@gmail.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tanu Midha, Assistant Professor, Department of Community Medicine, Government Medical College, National Highway 91, Kannauj, Uttar Pradesh 209732, India. tanumidha2001@gmail.com
Telephone: +91-933-5828435 Fax: +91-512-2535483
Received: July 29, 2014
Peer-review started: July 29, 2014
First decision: September 18, 2014
Revised: December 10, 2014
Accepted: December 29, 2014
Article in press: January 15, 2015
Published online: February 16, 2015
Processing time: 191 Days and 14.3 Hours
Abstract

AIM: To assess the correlation between blood pressure levels and fasting plasma glucose levels among young adults attending Chatrapati Shahuji Maharaj University, Kanpur, India.

METHODS: The present study was cross-sectional in nature, conducted among students in the Institute of Paramedical Sciences, Chatrapati Shahuji Maharaj University, Kanpur. Study subjects included 185 young adults. Among them, 94 were males and 91 were females, in the age group 17 to 19 years.

RESULTS: Mean age among males was 18.5 ± 1.5 years and among females was 17.9 ± 1.8 years. Of the total 185 study subjects, 61 (32.9%) were classified as pre-diabetic and 20 (10.8%) as pre-hypertensive. Mean waist circumference, systolic blood pressure and serum high density lipoprotein did not vary significantly between normoglycemic and pre-diabetic subjects. However, the mean diastolic blood pressure of pre-diabetics (82 ± 5 mmHg) was significantly higher than normoglycemics (79 ± 6 mmHg). Mean serum cholesterol, serum triglycerides, serum low density lipoprotein (LDL) and serum very low density lipoprotein was also higher among pre-diabetic subjects in comparison to normoglycemic subjects and the difference was statistically significant. Upon multiple linear regression analysis, it was observed that body mass index (BMI) (β = 0.149), diastolic blood pressure (β = 0.375) and serum LDL (β = 0.483) were significantly associated with fasting plasma glucose. Multiple linear regression with diastolic blood pressure as the outcome variable showed that BMI (β = 0.219), fasting blood glucose (β = 0.247) and systolic blood pressure (β = 0.510) were significantly associated.

CONCLUSION: A significant prevalence of pre-diabetes and pre-hypertension in young adults is a matter of concern therefore all young adults need to be targeted for screening of diabetes and hypertension and lifestyle modification.

Keywords: Adolescent; Hypertension; Diabetes; Co-prevalence; India

Core tip: In the present study, 32.9% young adults were pre-diabetic whereas 10.8% were pre-hypertensive. Around 2.7% young adults had both pre-diabetes and pre-hypertension. Among the pre-hypertensives, 25% also had pre-diabetes. However among the pre-diabetics, 8.2% had pre-hypertension. The correlation between systolic blood pressure and fasting plasma glucose was not statistically significant. However, the correlation between diastolic blood pressure and fasting plasma glucose was significant. The mean diastolic blood pressure of pre-diabetics (82 ± 5 mmHg) was significantly higher than normoglycemics (79 ± 6 mmHg). Upon multiple linear regression analysis, it was observed that body mass index (β = 0.149), diastolic blood pressure (β = 0.375) and serum LDL (β = 0.483) were significantly associated with fasting plasma glucose.