Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2025; 13(5): 95879
Published online Feb 16, 2025. doi: 10.12998/wjcc.v13.i5.95879
Importance of etiologies of secondary diabetes: How often do we think off in clinical practice?
Kotha Sugunakar Reddy, Arvind Kumar Morya, Archana Gaur, Sakthivadivel Varatharajan
Kotha Sugunakar Reddy, Sakthivadivel Varatharajan, Department of General Medicine, All India Institute of Medical Sciences, Hyderabad 508126, Telangana, India
Arvind Kumar Morya, Department of Ophthalmology, All India Institute of Medical Sciences, Hyderabad 508126, Telangana, India
Archana Gaur, Department of Physiology, All India Institute of Medical Sciences, Hyderabad 508126, Telangana, India
Author contributions: Morya AK and Varatharajan S designed the study; Reddy KS wrote the manuscript; Gaur A and Morya AK edited it and finally submitted by Morya AK.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arvind Kumar Morya, MS, MNAMS Professor, Department of Ophthalmology, All India Institute of Medical Sciences, Bibi Nagar, Hyderabad 508126, Telangana, India. bulbul.morya@gmail.com
Received: April 21, 2024
Revised: October 10, 2024
Accepted: November 4, 2024
Published online: February 16, 2025
Processing time: 211 Days and 22.5 Hours
Abstract

The article "Secondary diabetes due to different etiologies: Four case reports" by Song et al, published in the World Journal of Clinical Cases, delves into the identification of rare causes of secondary diabetes and emphasizes the necessity for healthcare professionals to recognize these conditions. Failure to do so can result in treatment delays and compromised patient outcomes. The article discusses specific types of diabetes, including maturity onset of diabetes in young, pancreas-related diseases, endocrinopathies, drug-induced diabetes, infections, and congenital genetic syndromes associated with diabetes mellitus. Case summaries highlight how patients with secondary diabetes, stemming from conditions such as Williams-Beuren syndrome and pituitary adenoma, often exhibit distinct characteristics overlooked in clinical practice. The authors stress the importance of a holistic diagnostic approach and advocate for proactive management through early intervention, including genetic tests and antibody detection. Increased awareness and education are crucial for timely identification and proper management, ultimately improving patient well-being. These findings prompt a call to action for healthcare professionals to consider rare causes of secondary diabetes, facilitating better glycemic control and overall patient care.

Keywords: Diabetes mellitus; Etiologies; Viral infections; Syndromes; Pathophysiology, Secondary diabetes mellitus, Clinical practice

Core Tip: The pathophysiology behind the origin of secondary diabetes mellitus (DM) is quite intricating. It is seen in many syndromes, drug-induced and commonly prevalent viral-infections. To know the etiology of secondary DM is of paramount importance for its proper management.