Wei CC, Huang YQ, Yu CH. Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients. World J Clin Cases 2025; 13(4): 95803 [PMID: 39917573 DOI: 10.12998/wjcc.v13.i4.95803]
Corresponding Author of This Article
Yu-Qing Huang, Doctor, Department of Cardiology, Guangdong Cardiovascular Institute, No. 106 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, Guangdong Province, China. hyq513@126.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Feb 6, 2025; 13(4): 95803 Published online Feb 6, 2025. doi: 10.12998/wjcc.v13.i4.95803
Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients
Cheng-Cheng Wei, Yu-Qing Huang, Cheng-Hong Yu
Cheng-Cheng Wei, Cheng-Hong Yu, Department of Cardiology, Tongxiang First People's Hospital, Tongxiang 314500, Zhejiang Province, China
Yu-Qing Huang, Department of Cardiology, Guangdong Cardiovascular Institute, Guangzhou 510080, Guangdong Province, China
Co-corresponding authors: Yu-Qing Huang and Cheng-Hong Yu.
Author contributions: Huang YQ acquired clinical data; Huang YQ and Yu CH have played important and indispensable roles in the design, data analysis, interpretation and manuscript preparation, conceptualized, designed, and supervised the whole process of the project, searched the literature, revised and submitted the early version of the manuscript, data re-analysis and re-interpretation, figure plotting, comprehensive literature search, preparation and submission of the current version of the revised manuscript; Wei CC, Huang YQ and Yu CH conceptualized and designed the research and wrote the paper; all of the authors read and approved the final version of the manuscript to be published.
Institutional review board statement: While all the pooled data in the present study was obtained from publicly available datasets that obtained relevant ethical approval and participant consent, the design and analysis of this study was also approved by the Ethics Committee of Guangdong Provincial People's Hospital (No. 2018292H).
Informed consent statement: We obtained relevant participant consent from participants.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data of this study were available upon request from the corresponding author of Huang YQ.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Corresponding author: Yu-Qing Huang, Doctor, Department of Cardiology, Guangdong Cardiovascular Institute, No. 106 Zhongshan 2nd Road, Yuexiu District, Guangzhou 510080, Guangdong Province, China. hyq513@126.com
Received: April 19, 2024 Revised: September 10, 2024 Accepted: November 1, 2024 Published online: February 6, 2025 Processing time: 210 Days and 1.5 Hours
Abstract
BACKGROUND
Dyslipidemia was strongly linked to stroke, however the relationship between dyslipidemia and its components and ischemic stroke remained unexplained.
AIM
To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive population.
METHODS
Between 2013 and 2014, 6094 hypertension individuals were included in this, and ischemic stroke cases were documented to the end of 2018. Longitudinal changes of lipid were stratified into four groups: (1) Normal was transformed into normal group; (2) Abnormal was transformed into normal group; (3) Normal was transformed into abnormal group; and (4) Abnormal was transformed into abnormal group. To examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke, we utilized multivariate Cox proportional hazards models with hazard ratio (HR) and 95%CI.
RESULTS
The average age of the participants was 62.32 years ± 13.00 years, with 329 women making up 54.0% of the sample. Over the course of a mean follow-up of 4.8 years, 143 ischemic strokes happened. When normal was transformed into normal group was used as a reference, after full adjustments, the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group, normal was transformed into abnormal group and abnormal was transformed into abnormal group were 1.089 (95%CI: 0.598-1.982; P = 0.779), 2.369 (95%CI: 1.424-3.941; P < 0.001) and 1.448 (95%CI: 1.002-2.298; P = 0.047) (P for trend was 0.233), respectively.
CONCLUSION
In individuals with hypertension, longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.
Core Tip: Longitudinal changes from normal to abnormal in total cholesterol was significantly related to the occurrence of ischemic stroke among hypertension. Longitudinal changes from normal to abnormal in low-density lipoprotein cholesterol was remarkably related to the occurrence of ischemic stroke among hypertension.
